Consulta: creatorFacets:"Joviano-Santos,J.V."
Registros recuperados: 1
Data/hora: 03/06/2024 00:40:42

Evaluation of cardiovascular toxicity of carbon nanotubes functionalized with sodium hyaluronate in oral regenerative medicine
Provedor de dados: 56
Autores: Joviano-Santos,J.V.; Sá,M.A.; De Maria,M.L.A.; Almeida,T.C.S.; Geraldo,V.; Oliveira,S.; Ladeira,L.O.; Ferreira,A.J.
It has been demonstrated that carbon nanotubes (CNTs) associated with sodium hyaluronate (HY-CNTs) accelerate bone repair in the tooth sockets of rats. Before clinical application of HY-CNTs, it is important to assess their biocompatibility. Moreover, cardiac toxicity may be caused by the translocation of these particles to the blood stream. The aim of this study was to evaluate possible changes in cardiovascular function in male Wistar rats whose tooth sockets were treated with either CNTs or HY-CNTs (100 μg/mL, 0.1 mL). Blood pressure and heart rate were monitored in conscious rats 7 days after treatment. Cardiac function was evaluated using the Langendorff perfusion technique. The data showed no changes in blood pressure or heart rate in rats treated...
Palavras-chave: Cardiac function; Blood pressure; Carbon nanotubes; Nanotechnology; Bone repair; Tooth sockets.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000700560