Consulta: creatorFacets:"Jung,Ho Jung"
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Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells
Provedor de dados: Biological Research
Autores: Bae,Seunghee; Lim,Kyung Mi; Cha,Hwa Jun; An,In-Sook; Lee,Jeong Pyo; Lee,Kwang Sik; Lee,Ghang Tai; Lee,Kun Kook; Jung,Ho Jung; Ahn,Kyu Joong; An,Sungkwan.
BACKGROUND: Accumulating evidence indicates that reactive oxygen species (ROS) are an important etiological factor for the induction of dermal papilla cell senescence and hair loss, which is also known alopecia. Arctiin is an active lignin isolated from Arctium lappa and has anti-inflammation, anti-microbial, and anti-carcinogenic effects. In the present study, we found that arctiin exerts anti-oxidative effects on human hair dermal papilla cells (HHDPCs). RESULTS: To better understand the mechanism, we analyzed the level of hydrogen peroxide (H2O2)-induced cytotoxicity, cell death, ROS production and senescence after arctiin pretreatment of HHDPCs. The results showed that arctiin pretreatment significantly inhibited the H2O2-induced reduction in cell...
Tipo: Journal article
Palavras-chave: Dermal papilla cell; Senescence; Cell death; MicroRNA; Arctiin.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100073