Consulta: creatorFacets:"Kapczinski,F."
Registros recuperados: 3
Data/hora: 09/06/2024 17:42:43

Dose-related effects of propericiazine in rats
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Cechin,E.M.; Quevedo,J.; Barichello,T.; Machado-Vieira,R.; Gentil,V.; Kapczinski,F.
We evaluated the effects of the neuroleptic agent propericiazine on animal models of anxiety and memory. Adult male Wistar rats (250 to 350 g) received intraperitoneal injections of propericiazine (0.05, 0.075 and 0.1 mg/kg), diazepam (1 mg/kg), saline, or diazepam vehicle (20% propylene glycol and 80% saline) 30 min prior to the experimental procedure. Animals (10-15 for each task) were tested for step-down inhibitory avoidance (0.3-mA footshock) and habituation to an open-field for memory assessment, and submitted to the elevated plus-maze to evaluate the effects of propericiazine in a model of anxiety. Animals treated with 0.075 mg/kg propericiazine showed a reduction in anxiety measures (P&lt;0.05) similar to that observed in those treated with...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Propericiazine; Memory; Anxiety; Diazepam; Elevated plus-maze.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000200010

Mirtazapine versus fluoxetine in the treatment of panic disorder
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ribeiro,L.; Busnello,J.V.; Kauer-Sant'Anna,M.; Madruga,M.; Quevedo,J.; Busnello,E.A.D.; Kapczinski,F.
Mirtazapine is an antidepressant whose side effect profile differs from that of first-line agents (selective serotonin reuptake inhibitors) used in the treatment of panic disorder. The present study compared the effect of mirtazapine and fluoxetine in the treatment of panic disorder in a double-blind, randomized, flexible-dose trial conducted with outpatients. After a 1-week single-blind placebo run-in, 27 patients entered an 8-week double-blind phase in which they were randomly assigned to treatment with either mirtazapine or fluoxetine. Both groups improved significantly in all but one efficacy measure (P&lt;=0.01). ANOVA showed no significant differences between the two treatment groups in number of panic attacks, Hamilton Anxiety Scale or Sheehan...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Mirtazapine; Fluoxetine; Panic disorder; Treatment; Randomized trial.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000010

Memory mood congruency phenomenon in bipolar I disorder and major depression disorder patients
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Delgado,V.B.; Kapczinski,F.; Chaves,M.L.F.
The objective of the present study was to evaluate memory performance in tasks with and without affective content (to confirm the mood congruency phenomenon) in acutely admitted patients with bipolar I disorder (BD) and major depression disorder (MDD) and in healthy participants. Seventy-eight participants (24 BD, 29 MDD, and 25 healthy controls) were evaluated. Three word lists were used as the memory task with affective content (positive, negative and indifferent). Psychiatric symptoms were also evaluated with rating scales (Young Mania Rating Scale for mania and Hamilton Depression Rating Scale for depression). Patients were selected during the first week of hospitalization. BD patients showed higher scores in the word span with positive tone than MDD...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Memory; Bipolar disorder; Depression; Affect.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900010