Consulta: creatorFacets:"Kerchove,C.M."
Registros recuperados: 1
Data/hora: 16/06/2024 06:58:27

Evaluation of the cholinomimetic actions of trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana (Gastropoda, Opisthobranchia)
Provedor de dados: 56
Autores: Kerchove,C.M.; Markus,R.P.; Freitas,J.C.; Costa-Lotufo,L.V.
Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable ability to inhibit cholinergic responses. In the present study, the pharmacological profile of trimethylsulfonium was characterized on muscarinic and nicotinic acetylcholine receptors. In rat jejunum the contractile response induced by trimethylsulfonium (pD2 = 2.46 ± 0.12 and maximal response = 2.14 ± 0.32 g) was not antagonized competitively by atropine. The maximal response (Emax) to trimethylsulfonium was diminished in the presence of increasing doses of atropine (P&lt;0.05), suggesting that trimethylsulfonium-induced contraction was not related to muscarinic stimulation, but might be caused by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aplysia brasiliana; Trimethylsulfonium; Cholinergic systems; Muscarinic acetylcholine receptors; Nicotinic acetylcholine receptors.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000400013