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Anti-inflammatory components of the Vietnamese starfish Protoreaster nodosus
Provedor de dados: 48
Autores: Thao,Nguyen Phuong; Luyen,Bui Thi Thuy; Koo,Jung Eun; Kim,Sohyun; Koh,Young Sang; Cuong,Nguyen Xuan; Nam,Nguyen Hoai; Van Kiem,Phan; Kim,Young Ho; Van Minh,Chau.
BACKGROUND: In the present study, we examined the inhibitory effects of a methanolic extract, dichloromethane fraction, water layer, and polyhydroxylated sterols (1-4) isolated from the Vietnamese starfish Protoreaster nodosus on pro-inflammatory cytokine (IL-12 p40, IL-6, and TNF-&amp;#945;) production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs) using enzyme-linked immunosorbent assays (ELISA). RESULTS: The methanolic extract and dichloromethane fraction exerted potent inhibitory effects on the production of all three pro-inflammatory cytokines, with IC50 values ranging from 0.60 ±0.01 to 26.19 ±0.64 &amp;#956;g/mL. Four highly pure steroid derivatives (1-4) were isolated from the dichloromethane fraction and water layer of P. nodosus....
Tipo: Journal article
Palavras-chave: Protoreaster nodosus Starfish IL-12 p40 IL-6 TNF-&amp;#945; LPS-stimulated BMDCs Anti-inflammatory.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100012