Consulta: creatorFacets:"Korish,Aida Abdelhamid"
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Data/hora: 03/06/2024 02:32:55

Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock
Provedor de dados: 55
Autores: Korish,Aida Abdelhamid; Arafa,Maha Mohamed.
BACKGROUND: Severe pathogenic infection triggers excessive release of cytokines as part of the massive inflammatory response associated with septic shock. OBJECTIVES: To investigate the protective effect of caffeic acid phenethye ester (CAPE) against lipopolysaccharide (LPS) induced endotoxemia, hepatic and neuronal damage and the associated systemic inflammatory response (SIR). METHODS: Fifty male Wister rats were divided into: control, LPS, and CAPE+LPS groups. Plasma concentrations of various cytokines, including TNF-α, IL-1α, IL-1β, IL-6, IL-4, IL-10, and sICAM-1 were evaluated. In addition, the histopathological changes in the hepatic and neural cells were assessed. RESULTS: The LPS group showed high inflammatory cytokines and sICAM-1 levels...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lipopolysaccharides; Septic shock; Systemic inflammatory response syndrome; Cytokines.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400006