Consulta: creatorFacets:"Kurzawski,M."
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Data/hora: 10/06/2024 17:57:44

The effect of 677C&gt;T and 1298A&gt;C MTHFR polymorphisms on sulfasalazine treatment outcome in rheumatoid arthritis
Provedor de dados: 56
Autores: Pawlik,A.; Kurzawski,M.; Gawronska-Szklarz,B.; Gornik,W.; Dziedziejko,V.; Safranow,K.; Juzyszyn,Z.; Drozdzik,M.
Despite the availability of several new agents for the treatment of rheumatoid arthritis (RA), sulfasalazine remains the mainstay because of both cost and experience with its use. Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and several polymorphisms have been described in the MTHFR gene. Of these, the 677C&gt;T and 1298A&gt;C polymorphisms have been associated with altered enzyme activity. To examine the association between 677C&gt;T and 1298A&gt;C MTHFR polymorphisms and sulfasalazine efficacy for the treatment of RA, a total of 117 RA patients treated with sulfasalazine (1 g daily; duration of treatment 17 ± 5 months) were analyzed. The 677C&gt;T and 1298 A&gt;C polymorphisms were detected using a PCR-RFLP method. RA was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MTHFR; Polymorphisms; Sulfasalazine; Rheumatoid arthritis.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000700011