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Effect of dietary linoleic acid on the progression of chronic renal failure in rats
Provedor de dados: 56
Autores: Gregório,S.M.P.; Lemos,C.C.S.; Caldas,M.L.; Bregman,R.
The role of linoleic acid in chronic renal failure (CRF) is controversial. In the present study 21 male Wistar rats submitted to 5/6 renal mass reduction (R) and 16 normal controls (C) were fed a supplement (S) or normal (N) linoleic acid diet for 60 days starting 10 days after CRF. As expected, serum creatinine, cholesterol and triglycerides (mean ± SEM) were higher in the CRF groups compared to the C groups (P&lt;0.05). The RS group presented lower cholesterol (84 ± 4 vs 126 ± 13 mg%) and triglyceride (88 ± 9 vs 132 ± 19 mg%) levels compared to the RN group. Proteinuria and kidney weight did not differ between CRF groups. Glomerular area increased 78% in RS and 100% in RN compared to control rats. Glomerular sclerosis index tended to be lower in RS (27%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic kidney failure; Diet; Glomeruli; Linoleic acid.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500010

Effect of castration on renal glycosaminoglycans and their urinary excretion in male and female rats with chronic renal failure
Provedor de dados: 56
Autores: Lemos,C.C.S.; Tovar,A.M.F.; Guimarães,M.A.M.; Bregman,R.
Glycosaminoglycans (GAGs) participate in a variety of processes in the kidney, and evidence suggests that gender-related hormones participate in renal function. The aim of this study was to analyze the relationship of GAGs, gender, and proteinuria in male and female rats with chronic renal failure (CRF). GAGs were analyzed in total kidney tissue and 24-h urine of castrated (c), male (M), and female (F) Wistar control (C) rats (CM, CMc, CF, CFc) and after 30 days of CRF induced by 5/6 nephrectomy (CRFM, CRFMc, CRFF, CRFFc). Total GAG quantification and composition were determined using agarose and polyacrylamide gel electrophoresis, respectively. Renal GAGs were higher in CF compared to CM. CRFM presented an increase in renal GAGs, heparan sulfate (HS), and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Castration; Chronic renal failure; Gender; Glycosaminoglycans; Proteinuria.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000700567