Consulta: creatorFacets:"Lins,Tulio C."
Registros recuperados: 2
Data/hora: 10/06/2024 01:25:07

Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
Provedor de dados: 74
Autores: Lins,Tulio C.; Vieira,Rodrigo G.; Grattapaglia,Dario; Pereira,Rinaldo W.
The vitamin D receptor (VDR) is an essential protein related to bone metabolism. Some VDR alleles are differentially distributed among ethnic populations and display variable patterns of linkage disequilibrium (LD). In this study, 200 unrelated Brazilians were genotyped using 21 VDR single nucleotide polymorphisms (SNPs) and 28 ancestry informative markers. The patterns of LD and haplotype distribution were compared among Brazilian and the HapMap populations of African (YRI), European (CEU) and Asian (JPT+CHB) origins. Conditional regression and haplotype-specific analysis were performed using estimates of individual genetic ancestry in Brazilians as a quantitative trait. Similar patterns of LD were observed in the 5' and 3' gene regions. However, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazilian population; HapMap; Haplotype; Population diversity; VDR.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300003

Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women
Provedor de dados: 74
Autores: Lins,Tulio C.; Pires,Alause S.; Paula,Roberta S.; Moraes,Clayton F.; Vieira,Rodrigo G.; Vianna,Lucy G.; Nobrega,Otávio T.; Pereira,Rinaldo W.
The prevalence of metabolic disorders varies among ethnic populations and these disorders represent a critical health care issue for elderly women. This study investigated the correlation between genetic ancestry and body composition, metabolic traits and clinical status in a sample of elderly women. Clinical, nutritional and anthropometric data were collected from 176 volunteers. Genetic ancestry was estimated using 23 ancestry-informative markers. Pearsons correlation test was used to examine the relationship between continuous variables and an independent samples t-test was used to compare the means of continuous traits within categorical variables. Overall ancestry was a combination of European (57.49%), Native American (25.78%) and African (16.73%)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dyslipidemia; Genetic ancestry; Lipid profile; Obesity; Postmenopausal women.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000400005