Consulta: creatorFacets:"MORALES,MARCELO M."
Registros recuperados: 2
Data/hora: 12/06/2024 12:44:12

Nanoparticle-based therapy for respiratory diseases
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: SILVA,ADRIANA L. DA; SANTOS,RAQUEL S.; XISTO,DÉBORA G.; ALONSO,SILVIA DEL V.; MORALES,MARCELO M.; ROCCO,PATRICIA R.M.
Nanotechnology is an emerging science with the potential to create new materials and strategies involving manipulation of matter at the nanometer scale (&lt;100 nm). With size-dependent properties, nanoparticles have introduced a new paradigm in pharmacotherapy – the possibility of cell-targeted drug delivery with minimal systemic side effects and toxicity. The present review provides a summary of published findings, especially regarding to nanoparticle formulations for lung diseases. The available data have shown some benefits with nanoparticle-based therapy in the development of the disease and lung remodeling in respiratory diseases. However, there is a wide gap between the concepts of nanomedicine and the published experimental data and clinical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Asthma; Turberculosis; Nanotechnology; Lung cancer.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100137

The Cystic Fibrosis Transmembrane Regulator (CFTR) in the kidney
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: MORALES,MARCELO M.; FALKENSTEIN,DORIS; LOPES,ANÍBAL GIL.
The cystic fibrosis transmembrane regulator (CFTR) is a Cl- channel. Mutations of this transporter lead to a defect of chloride secretion by epithelial cells causing the Cystic Fibrosis disease (CF). In spite of the high expression of CFTR in the kidney, patients with CF do not show major renal dysfunction, but it is known that both the urinary excretion of drugs and the renal capacity to concentrate and dilute urine is deficient. CFTR mRNA is expressed in all nephron segments and its protein is involved with chloride secretion in the distal tubule, and the principal cells of the cortical (CCD) and medullary (IMCD) collecting ducts. Several studies have demonstrated that CFTR does not only transport Cl- but also secretes ATP and, thus, controls other...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CFTR; Kidney; Nephron; Chloride channel.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300013