Consulta: creatorFacets:"Machado,Carlos Renato"
Registros recuperados: 2
Data/hora: 29/05/2024 05:59:12

DNA lesions and repair in trypanosomatids infection
Provedor de dados: 74
Autores: Repolês,Bruno M.; Machado,Carlos Renato; Florentino,Pilar T.V.
Abstract Pathological processes such as bacterial, viral and parasitic infections can generate a plethora of responses such as, but not restricted to, oxidative stress that can be harmful to the host and the pathogen. This stress occurs when there is an imbalance between reactive oxygen species produced and antioxidant factors produced in response to the infection. This imbalance can lead to DNA lesions in both infected cells as well as in the pathogen. The effects of the host response on the parasite lead to several kinds of DNA damage, causing alterations in the parasite’s metabolism; the reaction and sensitivity of the parasite to these responses are related to the DNA metabolism and life cycle of each parasite. The present review will discuss the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Reactive oxygen species; DNA repair.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200311

Assessment of genetic mutation frequency induced by oxidative stress in Trypanosoma cruzi
Provedor de dados: 74
Autores: Torres-Silva,Carolina Furtado; Repolês,Bruno Marçal; Ornelas,Hugo Oliveira; Macedo,Andréa Mara; Franco,Glória Regina; Junho Pena,Sérgio Danilo; Tahara,Erich Birelli; Machado,Carlos Renato.
Abstract Trypanosoma cruzi is the etiological agent of Chagas disease, a public health challenge due to its morbidity and mortality rates, which affects around 6-7 million people worldwide. Symptoms, response to chemotherapy, and the course of Chagas disease are greatly influenced by T. cruzi‘s intra-specific variability. Thus, DNA mutations in this parasite possibly play a key role in the wide range of clinical manifestations and in drug sensitivity. Indeed, the environmental conditions of oxidative stress faced by T. cruzi during its life cycle can generate genetic mutations. However, the lack of an established experimental design to assess mutation rates in T. cruzi precludes the study of conditions and mechanisms that potentially produce genomic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: T. cruzi; DNA; Mutation frequency; H2O2.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300466