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Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Pasin,J.S.M.; Ferreira,A.P.O.; Saraiva,A.L.L.; Ratzlaff,V.; Andrighetto,R.; Machado,P.; Marchesan,S.; Zanette,R.A.; Bonacorso,H.G.; Zanatta,N.; Martins,M.A.P.; Ferreira,J.; Mello,C.F.
The objective of this study was to determine the effect of eight 5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1-carboxyamidepyrazoles (TFDPs) on rat body temperature and baker’s yeast-induced fever. TFDPs or vehicle (5% Tween 80 in 0.9% NaCl, 5 mL/kg) were injected subcutaneously and rectal temperature was measured as a function of time in 28-day-old male Wistar rats (N = 5-12 per group). Antipyretic activity was determined in feverish animals injected with baker’s yeast (Saccharomyces cerevisiae suspension, 0.135 mg/kg, 10 mL/kg, ip). 3-Ethyl- and 3-propyl-TFDP (140 and 200 μmol/kg, respectively, 4 h after yeast injection) attenuated baker’s yeast-induced fever by 61 and 82%, respectively. These two effective antipyretics were selected for subsequent...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pyrazole derivatives; Fever; Cytokine levels; Cyclooxygenase.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200009