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Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice
Provedor de dados: 77
Autores: Sampannang,Apichakan; Arun,Supatcharee; Sukhorum,Wannisa; Burawat,Jaturon; Nualkaew,Somsak; Maneenin,Chanwit; Sripanidkulchai,Bungorn; Iamsaard,Sitthichai.
The aim of present study was to investigate the effect of Momordica cochinchinensis (Gag) aril (GA) aqueous extract on male reproductive system of streptozotocin (STZ)-induced hyperglycemia (HG) mice. GA were extracted with distilled water (DW) and analyzed for in vitro antioxidant capacities. ICR male mice were divided into 7 groups: 1) control, 2) DW, 3) GA 1000 mg/kg BW, 4) HG, 5) HG + glibenclamide, 6 and 7) HG + GA 500 and 1000 mg/kg BW respectively (7 mice/ group). In HG groups, mice were induced by STZ at single dose (150 mg/kg BW). They were treated for consecutive 35 days. All groups were compared for blood glucose levels, weights and histopathologies of reproductive organs, sperm concentration including testicular tyrosine phosphorylation protein...
Tipo: Journal article
Palavras-chave: Momordica cochinchinensis aril; Streptozotocin (STZ); Testicular damage; Testicular tyrosine phosphorylated protein; Hyperglycemia (HG) mice.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200046