Consulta: creatorFacets:"Marano,Leonardo Arduino"
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Evaluation of MC1R high-throughput nucleotide sequencing data generated by the 1000 Genomes Project
Provedor de dados: 74
Autores: Marano,Leonardo Arduino; Marcorin,Letícia; Castelli,Erick da Cruz; Mendes-Junior,Celso Teixeira.
Abstract The advent of next-generation sequencing allows simultaneous processing of several genomic regions/individuals, increasing the availability and accuracy of whole-genome data. However, these new approaches may present some errors and bias due to alignment, genotype calling, and imputation methods. Despite these flaws, data obtained by next-generation sequencing can be valuable for population and evolutionary studies of specific genes, such as genes related to how pigmentation evolved among populations, one of the main topics in human evolutionary biology. Melanocortin-1 receptor (MC1R) is one of the most studied genes involved in pigmentation variation. As MC1R has already been suggested to affect melanogenesis and increase risk of developing...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Melanocortin-1 Receptor; The 1000 Genomes Project; Next-generation sequencing.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300530