Consulta: creatorFacets:"Morais,Selene M."
Registros recuperados: 3
Data/hora: 04/06/2024 10:14:31

Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action
Provedor de dados: 42
Autores: Rodrigues,Patrícia A.; Morais,Selene M.; Souza,Carolina M.; Magalhães,Davi V.; Vieira,Ícaro G.P.; Andrade,Geanne M.; Rao,Vietla S.; Santos,Flávia A.
Byrsonima sericea leaves are extensively used in folk medicine in Brazil against gastric disorders. This study investigated the chemical constituents of B. sericea leaf ethanolic extract (BSLE) and its potential gastroprotective activity, with its possible mechanism of the action using ethanol to induce gastric mucosal damage in mice. The phytochemical analysis was carried out to identify the active constituents present in the extract, and the HPLC analysis was performed for the identification of flavonoids. BSLE at oral doses of 125, 250 and 500 mg/kg markedly attenuated the ethanol-evoked gastric lesions by 53.2, 84.9 and 87.6 %, respectively. The BSLE (250 mg/kg) prevented the depletion of gastric mucus and gastric mucosal nonproteic-sulfhydryl groups,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antioxidant; Byrsonima sericea; Flavonoids; Gastroprotection; Mechanisms of action.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000100011

Water extracts of Brazilian leguminous seeds as rich sources of larvicidal compounds against Aedes aegypti L.
Provedor de dados: 42
Autores: Farias,Davi F.; Cavalheiro,Mariana G.; Viana,Martônio P.; Queiroz,Vanessa A.; Rocha-Bezerra,Lady C.B.; Vasconcelos,Ilka M.; Morais,Selene M.; Carvalho,Ana F.U.
This study assessed the toxicity of seed water extracts of 15 leguminous species upon Aedes aegypti larvae. A partial chemical and biochemical characterization of water extracts, as well as the assessment of their acute toxicity in mice, were performed. The extracts of Amburana cearensis, Anadenanthera macrocarpa, Dioclea megacarpa, Enterolobium contortisiliquum and Piptadenia moniliformis caused 100% of mortalit y after 1 to 3 h of exposure. They showed LC50 and LC90 values ranging from 0.43 ± 0.01 to 9.06 ± 0.12 mg/mL and from 0.71 ± 0.02 to 13.03 ± 0.15 mg/mL, respectively. Among the secondary metabolite constituents, the seed water extracts showed tannins, phenols, flavones, favonols, xanthones, saponins and alkaloids. The extracts also showed high...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aedes aegypti; Larvicidal compounds; Leguminous seeds; Water extracts.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000300006

Anthelmintic acetogenin from Annona squamosa L. Seeds
Provedor de dados: 42
Autores: Souza,Marta M.C.; Bevilaqua,Claudia M.L.; Morais,Selene M.; Costa,Cícero T.C.; Silva,Ana R.A.; Braz-Filho,Raimundo.
Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml-1. The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Haemonchus contortus; Nematodes; Annonacea; Phytotherapy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000200005