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Structural biology of chemokine receptors
Provedor de dados: Biological Research
Autores: ROJO,DANIEL; SUETOMI,KATSUTOSHI; NAVARRO,JAVIER.
Chemokine receptors are G protein-coupled receptors that mediate migration and activation of leukocytes as an important part of a protective immune response to injury and infection. In addition, chemokine receptors are used by HIV-1 to infect CD4 positive cells. The structural bases of chemokine receptor recognition and signal transduction are currently being investigated. High-resolution X-ray diffraction and NMR spectroscopy of chemokines indicate that all these peptides exhibit a common folding pattern, in spite of its low degree of primary-sequence homology. Chemokines' functional motifs have been identified by mutagenesis studies, and a possible mechanism for receptor recognition and activation is proposed, but high-resolution structure data of...
Tipo: Journal article
Palavras-chave: Chemokines; G-protein coupled receptors; Inflammation; HIV-1.
Ano: 1999
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97601999000400006