Consulta: creatorFacets:"Nahrevanian,Hossein"
Registros recuperados: 4
Data/hora: 16/06/2024 16:48:02

An overview of a diagnostic and epidemiologic reappraisal of cutaneous leishmaniasis in Iran
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Farahmand,Mahin; Nahrevanian,Hossein; Shirazi,Hasti Atashi; Naeimi,Sabah; Farzanehnejad,Zahra.
Cutaneous leishmaniasis (CL) is a widespread tropical infection which has a high incidence rate in Iran. Leishmania tropica, the causative agent of anthroponotic cutaneous leishmaniasis (ACL), and Leishmania major, which causes zoonotic cutaneous leishmaniasis (ZCL), are endemic in various parts of Iran with a high incidence rate. The aim of this study was to evaluate the reappraisal of the diagnosis and epidemiology of CL in Iran, by different clinical, parasitological and molecular assays among patients suspected of CL referred to the Department of Parasitology, at the Pasteur Institute of Iran during 2006-2009. Two hundred samples from patients with ulcerative skin lesions were collected, clinical analyses were applied, data questionnaire was completed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Parasitological analysis; Molecular biology; Leishmaniasis; Cutaneous; Iran; Epidemiology.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100004

Involvement of nitric oxide and its up/down stream molecules in the immunity against parasitic infections
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Nahrevanian,Hossein.
Nitric oxide (NO) is a potent mediator with diverse roles in regulating cellular functions and signaling pathways. The NO synthase (NOS) enzyme family consists of three major isoforms, which convey variety of messages between cells, including signals for vasorelaxation, neurotransmission and cytotoxicity. This family of enzymes are generally classified as neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible NOS (iNOS). Increased levels of NO are induced from iNOS during infection; while eNOS and nNOS may be produced at the baseline in normal conditions. An association of some key cytokines appears to be essential for NOS gene regulation in the immunity of infections. Accumulating evidence indicates that parasitic diseases are commonly associated with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: INOS; Nitric oxide; NO; Immunity; Helminth; Parasite; Protozoa.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600010

Biochemical association between essential trace elements and susceptibility to Leishmania major in BALB/c and C57BL/6 mice
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Amini,Marzyeh; Nahrevanian,Hossein; Khatami,Shohreh; Farahmand,Mahin; Mirkhani,Fatemeh; Javadian,Seifoddin.
Several enzymes that contribute to immune system responses require zinc and copper as trace elements for their activity. We examined zinc and copper levels in two susceptible Balb/c mouse lines and resistant C57bl/6 mice infected with Leishmania major MRHO/IR/75/ER, a prevalent strain that causes cutaneous leishmaniasis in Iran. Serum Zn and Cu were determined by flame atomic absorption spectrophotometry. Higher Cu levels were found in infected C57bl/6 mice and higher Zn levels were found in infected Balb/c mice. Also, Cu/Zn ratios were increased in both the Balb/c and the C57bl/6 mice. We conclude that concentrations of essential trace elements vary during cutaneous leishmaniasis infection and that this variation is associated with...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Balb/c; C57bl/6; CL; Iran; Leishmania major; Treatment; Cu; Zn.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200002

Immune effector mechanisms of the nitric oxide pathway in malaria: cytotoxicity versus cytoprotection
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Nahrevanian,Hossein.
Nitric oxide (NO) is thought to be an important mediator and critical signaling molecule for malaria immunopathology; it is also a target for therapy and for vaccine. Inducible nitric oxide synthase (iNOS) is synthesized by a number of cell types under inflammatory conditions. The most relevant known triggers for its expression are endotoxins and cytokines. To date, there have been conflicting reports concerning the clinical significance of NO in malaria. Some researchers have proposed that NO contributes to the development of severe and complicated malaria, while others have argued that NO has a protective role. Infection with parasites resistant to the microbicidal action of NO may result in high levels of NO being generated, which could then damage the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: INOS; Malaria; Nitric oxide; NO; RNI.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400014