Consulta: creatorFacets:"Nam,Tae-gyu"
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Data/hora: 10/06/2024 19:14:23

BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis
Provedor de dados: 48
Autores: Kang,Youra; Timilshina,Maheshwor; Nam,Tae-gyu; Jeong,Byeong-Seon; Chang,Jae-Hoon.
Abstract  Background  CD4+ T cells play an important role in the initiation of an immune response by providing help to other cells. Among the helper T subsets, interferon-&amp;#947; (IFN-&amp;#947;)-secreting T helper 1 (Th1) and IL-17-secreting T helper 17 (Th17) cells are indispensable for clearance of intracellular as well as extracellular pathogens. However, Th1 and Th17 cells are also associated with pathogenesis and contribute to the progression of multiple inflammatory conditions and autoimmune diseases.  Results  In the current study, we found that BJ-1108, a 6-aminopyridin-3-ol analogue, significantly inhibited Th1 and Th17 differentiation in vitro in a concentration-dependent manner, with no effect on proliferation or apoptosis of activated T...
Tipo: Journal article
Palavras-chave: BJ-1108; Th1/Th17 cell; Differentiation; EAE.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100202