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Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium
Provedor de dados: 56
Autores: Conde Garcia,E.A.; Nascimento,V.T.; Santiago Santos,A.B.
Many pharmacological effects have been ascribed to extracts of Psidium guajava L. (guava) leaves. However, in spite of its widespread use in Brazilian folk medicine and a reasonable number of scientific reports about it, we could not find any study dealing with its action on the mammalian myocardium. In the present study, by measuring isometric force, we observed that the crude extract of P. guajava (water-alcohol extract obtained by macerating dry leaves) depresses the guinea pig atrial contractility in a concentration-dependent fashion (N = 8 hearts, 15 trials). The compound with cardiac activity was concentrated by extraction in a Soxhlet apparatus using 17 M glacial acetic acid after removing the less polar fractions (hexane, chloroform, acetone,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heart contractility; Guinea pig; Myocardial inotropism; Psidium guajava L.; Folk medicine.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500014