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Antiviral Effects of a Synthetic Aluminium-Magnesium Silicate on Avian Influenza Virus
Provedor de dados: Nature Precedings
Autores: Madike Ezeibe; Anthony Egbuji; Obianuju Okoroafor; James Eze; Omadi Ijabo; Augustine Ngene; Ikechukwu Eze; Joeseph Ugonabo; Mary Sanda; Ijeoma Mbuko.
Effects of a synthetic Aluminium-Magnesium Silicate (AMS) on Avian Influenza Virus (AIV) were tested. Equal amounts of H5N1 AIV samples and of AMS were mixed, left one hour, at room temperature before centrifuging. The supernatants were remeasured and tested for viral titre, for Mean Death Time (MDT) and Embryo Mortality Rate (EMR) of chicken eggs. Volumes of the viral samples reduced at rate of 23.4 &amp;#xb1; 5.48 %. Viral titres reduced significantly (P from HA, 73 &amp;#xb1; 32.72 to 1.4 &amp;#xb1;0.43). Also, mortality of infected embryos reduced from 100 % to 65% while MDT of those that died, increased significantly (P = 0.001) from 76 &amp;#xb1; 4.38 to 130 &amp;#xb1;17.27 hours.  When incubation with AMS was repeated on portions of the same sample,...
Tipo: Manuscript
Palavras-chave: Microbiology.
Ano: 2011
URL: http://precedings.nature.com/documents/6509/version/1

Aluminium - Magnesium Silicate enhances antibacterial activity of Ampicillin trihydrate, against Salmonella gallinarum
Provedor de dados: Nature Precedings
Autores: Madike Ezeibe; George Anosa; Okechi Okorie; Nnenna Elendu-Eleke; Obianuju Okoroafor; Augustine Ngene; Ogechukwu Chikelu.
Solutions of different concentrations, of Ampicillin trihydrate (AT) and of a formulation of AT in Aluminium Magnesium Silicate (AMS), were used for sensitivity test on Salmonella gallinarum cultures. Also, S. gallinarum-infected chicks were treated with; 10 mg / Kg (AT), 10 mg / Kg (AT in AMS), 7.5 mg / Kg ( AT), 7.5 mg /Kg (AT in AMS). Mean inhibition area, 28.39 mm produced by AT did not vary significantly (P ) from 26.36 mm produced by AT in AMS. However, 17.5 105 Salmonella gallinarum culture forming units per ml of bile of the untreated chicks and 3.4 105 (80.58 % reduction), 2.5 105 (85.7 % reduction) , 5.4 105 (69.2 % reduction ) and 0.38 105 (97.8 % reduction ) of the respective treated groups, showed AMS significantly (P 0.01) improved AT`s...
Tipo: Manuscript
Palavras-chave: Pharmacology.
Ano: 2012
URL: http://precedings.nature.com/documents/6814/version/1