Consulta: creatorFacets:"Ono,Michio"
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Data/hora: 10/06/2024 16:19:55

Inhibition of Rho-associated kinases disturbs the collective cell migration of stratified TE-10 cells
Provedor de dados: 48
Autores: Mikami,Taro; Yoshida,Keiichiro; Sawada,Hajime; Esaki,Michiyo; Yasumura,Kazunori; Ono,Michio.
BACKGROUND: The collective cell migration of stratified epithelial cells is considered to be an important phenomenon in wound healing, development, and cancer invasion; however, little is known about the mechanisms involved. Furthermore, whereas Rho family proteins, including RhoA, play important roles in cell migration, the exact role of Rho-associated coiled coil-containing protein kinases (ROCKs) in cell migration is controversial and might be cell-type dependent. Here, we report the development of a novel modified scratch assay that was used to observe the collective cell migration of stratified TE-10 cells derived from a human esophageal cancer specimen. RESULTS: Desmosomes were found between the TE-10 cells and microvilli of the surface of the cell...
Tipo: Journal article
Palavras-chave: Collective cell migration; Stratified epithelium; TE-10 cells; Rho-associated coiled coil-containing protein kinase; SiRNA.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100048