Consulta: creatorFacets:"PINZ,MIKAELA P."
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Data/hora: 04/06/2024 05:36:56

Antioxidant effect of quinoline derivatives containing or not selenium: Relationship with antinociceptive action quinolines are antioxidant and antinociceptive
Provedor de dados: 42
Autores: WILHELM,ETHEL A.; FERREIRA,ANA TERESINHA; PINZ,MIKAELA P.; REIS,ANGÉLICA S. DOS; VOGT,ANE G.; STEIN,ANDRE L.; ZENI,GILSON; LUCHESE,CRISTIANE.
ABSTRACT The present study investigated the antioxidant effect of a new class of quinoline derivatives (a-d) on assays in vitro. Lipid peroxidation, thiol peroxidase-like and free radical scavenging activities were determined to evaluate antioxidant activity of compounds. Thiol oxidase-like and δ-aminolevulinate dehydratase activities were performed as a toxicological parameter. A second objective of this study was to evaluate the in vivo antinociceptive effect of the compound with better antioxidant effect and without toxic effects in a model of nociception induced by formalin in mice. In liver, at 100 µM, compound a reduced the lipid peroxidation to the control levels, while compounds c and d partially reduced it. In brain, only compound d partially...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antinociceptive; Antiedematogenic; Anti-inflammatory; Antioxidant; Quinoline.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200457