Consulta: creatorFacets:"Palermo-Neto,J."
Registros recuperados: 5
Data/hora: 09/06/2024 02:49:18

Dose-response effects of systemic anandamide administration in mice sequentially submitted to the open field and elevated plus-maze tests
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ribeiro,A.; Ferraz-de-Paula,V.; Pinheiro,M.L.; Palermo-Neto,J.
The endocannabinoid system is involved in the control of many physiological functions, including the control of emotional states. In rodents, previous exposure to an open field increases the anxiety-like behavior in the elevated plus-maze. Anxiolytic-like effects of pharmacological compounds that increase endocannabinoid levels have been well documented. However, these effects are more evident in animals with high anxiety levels. Several studies have described characteristic inverted U-shaped dose-response effects of drugs that modulate the endocannabinoid levels. However, there are no studies showing the effects of different doses of exogenous anandamide, an endocannabinoid, in animal models of anxiety. Thus, in the present study, we determined the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Endocannabinoid; Anandamide; Anxiety; Open field; Elevated plus-maze.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600013

Effects of diazepam on Mycobacterium bovis-induced infection in hamsters
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Righi,D.A.; Pinheiro,S.R.; Guerra,J.L.; Palermo-Neto,J.
The in utero exposure of hamsters to low doses of diazepam results in impaired host defense against Mycobacterium bovis during adulthood. Delayed developmental immunotoxicity, however, represents a specific situation that might not be general. The present experiment was undertaken to investigate the effects of diazepam on hamster resistance to M. bovis using adult animals. The effects of diazepam treatment on serum cortisol levels were also studied. Adult hamsters (N = 10 for each group) were treated with diazepam (E1 = 1.0, E2 = 2.0 or E3 = 3.0 mg kg-1 day-1 subcutaneously) or with control solution (C) for 30 days. Seven days after the beginning of the treatment, the animals received identical inoculum concentrations of M. bovis. Hamsters treated with the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium bovis; Host resistance; Macrophages; Diazepam; Immune system.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900014

Effect of cyhalothrin on Ehrlich tumor growth and macrophage activity in mice
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Quinteiro-Filho,W.M.; Righi,D.A.; Palermo-Neto,J.
Cyhalothrin, a pyrethroid insecticide, induces stress-like symptoms, increases c-fos immunoreactivity in the paraventricular nucleus of the hypothalamus, and decreases innate immune responses in laboratory animals. Macrophages are key elements in cellular immune responses and operate at the tumor-host interface. This study investigated the relationship among cyhalothrin effects on Ehrlich tumor growth, serum corticosterone levels and peritoneal macrophage activity in mice. Three experiments were done with 10 experimental (single gavage administration of 3.0 mg/kg cyhalothrin daily for 7 days) and 10 control (single gavage administration of 1.0 mL/kg vehicle of cyhalothrin preparation daily for 7 days) isogenic BALB/c mice in each experiment. Cyhalothrin i)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cyhalothrin; Corticosterone; Macrophage; Ehrlich tumor; Innate immunity; HPA axis.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001000006

Differential behavioral outcomes of 3,4-methylenedioxymethamphetamine (MDMA-ecstasy) in anxiety-like responses in mice
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ferraz-de-Paula,V.; Stankevicius,D.; Ribeiro,A.; Pinheiro,M.L.; Rodrigues-Costa,E.C.; Florio,J.C.; Lapachinske,S.F.; Moreau,R.L.M.; Palermo-Neto,J.
Anxiolytic and anxiogenic-like behavioral outcomes have been reported for methylenedioxymethamphetamine (MDMA or ecstasy) in rodents. In the present experiment, we attempted to identify behavioral, hormonal and neurochemical outcomes of MDMA treatment to clarify its effects on anxiety-related responses in 2-month-old Balb/c male mice (25-35 g; N = 7-10 mice/group). The behavioral tests used were open field, elevated plus maze, hole board, and defensive behavior against predator odor. Moreover, we also determined striatal dopamine and dopamine turnover, and serum corticosterone levels. MDMA was injected ip at 0.2, 1.0, 5.0, 8.0, 10, or 20 mg/kg. MDMA at 10 mg/kg induced the following significant (P &lt; 0.05) effects: a) a dose-dependent increase in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Corticosterone; Open field; Plus maze; Hole board; Predator odor test; Ecstasy.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000500008

Developmental and behavioral effects of postnatal amitraz exposure in rats
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Palermo-Neto,J.; Sakaté,M.; Flório,J.C.
The effects of postnatal amitraz exposure on physical and behavioral parameters were studied in Wistar rats, whose lactating dams received the pesticide (10 mg/kg) orally on days 1, 4, 7, 10, 13, 16 and 19 of lactation; control dams received distilled water (1 ml/kg) on the same days. A total of 18 different litters (9 of them control and 9 experimental) born after a 21-day gestation were used. The results showed that the median effective time (ET50) for fur development, eye opening, testis descent and onset of the startle response were increased in rats postnatally exposed to amitraz (2.7, 15.1, 21.6 and 15.3 days, respectively) compared to those of the control pups (1.8, 14.0, 19.9 and 12.9 days, respectively). The ages of incisor eruption, total...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pesticide neurotoxicology; Amitraz; Lactation; Behavioral teratology.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800013