Consulta: creatorFacets:"Peña,Juan Pedro"
Registros recuperados: 1
Data/hora: 29/05/2024 03:32:32

IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction
Provedor de dados: Biological Research
Autores: Ávalos,Ana María; Apablaza,Felipe A; Quiroz,Mariana; Toledo,Viviana; Peña,Juan Pedro; Michea,Luis; Irarrazabal,Carlos E; Carrión,Flavio A; Figueroa,Fernando E.
Th17 cells, a recently described subtype of CD4+ effector lymphocytes, have been linked to cell-mediated autoimmune and inflammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defined. We therefore conducted the present study to evaluate IL-17A and Th17-related cytokine levels in a rat model of myocardial infarction (MI). MI was induced in male Sprague Dawley rats by coronary artery ligation. Controls were sham-operated (Sh) or non-operated (C). Blood and samples from the left ventricle (LV) were collected at weeks 1 and 4 post-MI. At week 1, MI animals exhibited increased IL-6, IL-23 and TGF-&amp;#946; mRNA levels with no apparent change in IL-17 mRNA or protein...
Tipo: Journal article
Palavras-chave: Interleukin-17; Th17; Myocardial infarction; Cardiovascular disease.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000200012