Consulta: creatorFacets:"Pereira,L.M.M.B."
Registros recuperados: 3
Data/hora: 09/06/2024 06:28:37

MTP -493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Siqueira,E.R.F.; Oliveira,C.P.M.S.; Correa-Giannella,M.L.; Stefano,J.T.; Cavaleiro,A.M.; Fortes,M.A.H.Z.; Muniz,M.T.C.; Silva,F.S.; Pereira,L.M.M.B.; Carrilho,F.J.
The reduction of hepatic microsomal transfer protein (MTP) activity results in fatty liver, worsening hepatic steatosis and fibrosis in chronic hepatitis C (CHC). The G allele of the MTP gene promoter, -493G/T, has been associated with lower transcriptional activity than the T allele. We investigated this association with metabolic and histological variables in patients with CHC. A total of 174 untreated patients with CHC were genotyped for MTP -493G/T by direct sequencing using PCR. All patients were negative for markers of Wilson’s disease, hemochromatosis and autoimmune diseases and had current and past daily alcohol intake lower than 100 g/week. The sample distribution was in Hardy-Weinberg equilibrium. Among subjects with genotype 1, 56.8% of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Steatosis; Fibrosis; Microsomal transfer protein.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100012

Hepatitis C virus infection in a Brazilian population with sickle-cell anemia
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Torres,M.C.M.R.; Pereira,L.M.M.B.; Ximenes,R.A.A.; Araújo,A.S.; Secaf,M.; Rodrigues,S.S.; Bezerra,A.C.S.; Conceição,I.B.; Valença,M.I.B.; Martinelli,A.L.C.
Patients with sickle-cell anemia submitted to frequent blood transfusions are at risk of contamination with hepatitis C virus (HCV). Determination of HCV RNA and genotype characterization are parameters that are relevant for the treatment of the viral infection. The objective of the present study was to determine the frequency of HCV infection and the positivity for HCV RNA and to identify the HCV genotype in patients with sickle-cell anemia with a history of blood transfusion who had been treated at the Hospital of the HEMOPE Foundation. Sera from 291 patients were tested for anti-HCV antibodies by ELISA 3.0 and RIBA 3.0 Chiron and for the presence of HCV RNA by RT-PCR. HCV genotyping was performed in 19 serum samples. Forty-one of 291 patients (14.1%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Anti-HCV antibodies; HCV RNA; HCV genotype; Sickle-cell anemia.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000300006

Geographic distribution of hepatitis C virus genotypes in Brazil
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Campiotto,S.; Pinho,J.R.R.; Carrilho,F.J.; Da Silva,L.C.; Souto,F.J.D.; Spinelli,V.; Pereira,L.M.M.B.; Coelho,H.S.M.; Silva,A.O.; Fonseca,J.C.; Rosa,H.; Lacet,C.M.C.; Bernardini,A.P.
Brazil is a country of continental dimension with a population of different ethnic backgrounds. Thus, a wide variation in the frequencies of hepatitis C virus (HCV) genotypes is expected to occur. To address this point, 1,688 sequential samples from chronic HCV patients were analyzed. HCV-RNA was amplified by the RT-PCR from blood samples collected from 1995 to 2000 at different laboratories located in different cities from all Brazilian States. Samples were collected in tubes containing a gel separator, centrifuged in the site of collection and sent by express mail in a refrigerated container to Laboratório Bioquímico Jardim Paulista, São Paulo, SP, Brazil. HCV- RNA was extracted from serum and submitted to RT and nested PCR using standard procedures....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; Hepatitis C virus; Genotypes; Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100007