Consulta: creatorFacets:"Pereira,Rinaldo W."
Registros recuperados: 4
Data/hora: 10/06/2024 03:35:11

Population analysis of vitamin D receptor polymorphisms and the role of genetic ancestry in an admixed population
Provedor de dados: 74
Autores: Lins,Tulio C.; Vieira,Rodrigo G.; Grattapaglia,Dario; Pereira,Rinaldo W.
The vitamin D receptor (VDR) is an essential protein related to bone metabolism. Some VDR alleles are differentially distributed among ethnic populations and display variable patterns of linkage disequilibrium (LD). In this study, 200 unrelated Brazilians were genotyped using 21 VDR single nucleotide polymorphisms (SNPs) and 28 ancestry informative markers. The patterns of LD and haplotype distribution were compared among Brazilian and the HapMap populations of African (YRI), European (CEU) and Asian (JPT+CHB) origins. Conditional regression and haplotype-specific analysis were performed using estimates of individual genetic ancestry in Brazilians as a quantitative trait. Similar patterns of LD were observed in the 5' and 3' gene regions. However, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazilian population; HapMap; Haplotype; Population diversity; VDR.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300003

Frequency of the CCRdelta32 allele in Brazilians: a study in colorectal cancer and in HTLV-I infection
Provedor de dados: 74
Autores: Pereira,Rinaldo W.; Pires,Edina R.; Duarte,Ana P.M.; Moura,Ricardo P. de; Monteiro,Elisangela; Torloni,Humberto; Proietti,Anna B.; Simpson,Andrew J.G.; Pena,Sérgio D.J.
The identification of a 32-bp deletion in the cc-chemokine receptor-5 gene (CCR5delta32 allele) that renders homozygous individuals highly resistant to HIV infection has prompted worldwide investigations of the frequency of the CCR5delta32 allele in regional populations. It is important to ascertain if CCR5delta32 is a factor to be considered in the overall epidemiology of HIV in individual populations. With this in mind we determined the CCR5delta32 allele frequency in a large sample (907 individuals) of the southeastern Brazilian urban population, stratified as follows: 322 healthy unrelated individuals, 354 unselected colorectal cancer patients, and 229 blood donors. The three groups displayed essentially identical allelic frequencies of CCR5delta32 and...
Tipo: Info:eu-repo/semantics/article
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572000000300003

Screening fetal losses for monosomy X with a simple PCR-based procedure
Provedor de dados: 74
Autores: Pereira,Rinaldo W.; Sturzeneker,Rosane; Pena,Sérgio D.J.
To screen for monosomy X in spontaneous fetal losses we explored a simple molecular strategy based on loss of heterozygosity at highly polymorphic X-linked loci. We developed a multiplex fluorescent procedure that allows the simultaneous amplification of five dinucleotide repeat polymorphisms in a large low-recombination region in the long arm of the X chromosome. Analysis was performed by computer-assisted laser densitometry. We did not find any instances of homozygosity at all five loci in 30 normal females tested, nor among 37 women whose typing data were retrieved from the Fondation Jean Dausset - CEPH genotype database. In addition, all cases of monosomy X previously diagnosed by conventional cytogenetics presented the anticipated loss of...
Tipo: Info:eu-repo/semantics/article
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572000000100002

Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women
Provedor de dados: 74
Autores: Lins,Tulio C.; Pires,Alause S.; Paula,Roberta S.; Moraes,Clayton F.; Vieira,Rodrigo G.; Vianna,Lucy G.; Nobrega,Otávio T.; Pereira,Rinaldo W.
The prevalence of metabolic disorders varies among ethnic populations and these disorders represent a critical health care issue for elderly women. This study investigated the correlation between genetic ancestry and body composition, metabolic traits and clinical status in a sample of elderly women. Clinical, nutritional and anthropometric data were collected from 176 volunteers. Genetic ancestry was estimated using 23 ancestry-informative markers. Pearsons correlation test was used to examine the relationship between continuous variables and an independent samples t-test was used to compare the means of continuous traits within categorical variables. Overall ancestry was a combination of European (57.49%), Native American (25.78%) and African (16.73%)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dyslipidemia; Genetic ancestry; Lipid profile; Obesity; Postmenopausal women.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000400005