Consulta: creatorFacets:"Pires,L.C."
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Effect of (+)-dehydrofukinone on GABAA receptors and stress response in fish model
Provedor de dados: 56
Autores: Garlet,Q.I.; Pires,L.C.; Silva,D.T.; Spall,S.; Gressler,L.T.; Bürger,M.E.; Baldisserotto,B.; Heinzmann,B.M.
(+)-Dehydrofukinone (DHF) is a major component of the essential oil of Nectandra grandiflora (Lauraceae), and exerts a depressant effect on the central nervous system of fish. However, the neuronal mechanism underlying DHF action remains unknown. This study aimed to investigate the action of DHF on GABAA receptors using a silver catfish (Rhamdia quelen) model. Additionally, we investigated the effect of DHF exposure on stress-induced cortisol modulation. Chemical identification was performed using gas chromatography-mass spectrometry and purity was evaluated using gas chromatography with a flame ionization detector. To an aquarium, we applied between 2.5 and 50 mg/L DHF diluted in ethanol, in combination with 42.7 mg/L diazepam. DHF within the range of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sedation; Anesthesia; Rhamdia quelen; Nectandra grandiflora; Cortisol.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000100607