Consulta: creatorFacets:"Porto,Maria Aurélia F."
Registros recuperados: 1
Data/hora: 08/06/2024 18:55:02

Spontaneous neutrophil activation in HTLV-1 infected patients
Provedor de dados: 55
Autores: Guerreiro,Jaqueline B.; Porto,Maria Aurélia F.; Santos,Silvane B.; Lacerda,Lino; Ho,John L.; Carvalho,Edgar M.
Human T cell lymphotropic Virus type-1 (HTLV-1) induces lymphocyte activation and proliferation, but little is known about the innate immune response due to HTLV-1 infection. We evaluated the percentage of neutrophils that metabolize Nitroblue tetrazolium (NBT) to formazan in HTLV-1 infected subjects and the association between neutrophil activation and IFN-gamma and TNF-alpha levels. Blood was collected from 35 HTLV-1 carriers, from 8 patients with HAM/TSP (HTLV-1- associated myelopathy); 22 healthy individuals were evaluated for spontaneous and lipopolysaccharide (LPS)-stimulated neutrophil activity (reduction of NBT to formazan). The production of IFN-gamma and TNF-alpha by unstimulated mononuclear cells was determined by ELISA. Spontaneous NBT levels,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; IFN-gamma; TNF-alpha; LPS; Neutrophil activation.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600010