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Active human Cytomegalovirus infection and Glycoprotein B genotypes in Brazilian pediatric renal or hematopoietic stem cell transplantation patients
Provedor de dados: Brazilian Journal of Microbiology
Autores: Dieamant,Débora de Campos; Bonon,Sandra Helena Alves; Prates,Liliane Cury; Belangelo,Vera Maria Santoro; Pontes,Erika R.; Costa,Sandra Cecília Botelho.
A prospective analysis of active Human Cytomegalovirus infection (HCMV) was conducted on 33 pediatric renal or hematopoietic stem cell post-transplant patients. The HCMV-DNA positive samples were evaluated for the prevalence of different gB subtypes and their subsequent correlation with clinical signs. The surveillance of HCMV active infection was based on the monitoring of antigenemia (AGM) and on a nested polymerase chain reaction (N-PCR) for the detection of HCMV in the patients studied. Using restriction analysis of the gB gene sequence by PCR-RFLP (Restriction Fragment Length Polymorphism), different HCMV strains could be detected and classified in at least four HCMV genotypes. Thirty-three pediatric recipients of renal or bone marrow transplantation...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytomegalovirus; Pediatric transplantation; GB genotypes; PCR; Antigenemia.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000100010