Consulta: creatorFacets:"Pujol, Pascal"
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Data/hora: 09/06/2024 05:49:47

Is adaptive therapy natural?
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Thomas, Frederic; Donnadieu, Emmanuel; Charriere, Guillaume; Jacqueline, Camille; Tasiemski, Aurelie; Pujol, Pascal; Renaud, Francois; Roche, Benjamin; Hamede, Rodrigo; Brown, Joel; Gatenby, Robert; Ujvari, Beata.
Research suggests that progression-free survival can be prolonged by integrating evolutionary principles into clinical cancer treatment protocols. The goal is to prevent or slow the proliferation of resistant malignant cell populations. The logic behind this therapy relies on ecological and evolutionary processes. These same processes would be available to natural selection in decreasing the probability of an organism's death due to cancer. We propose that organisms' anticancer adaptions include not only ones for preventing cancer but also ones for directing and retarding the evolution of life-threatening cancer cells. We term this last strategy natural adaptive therapy (NAT). The body's NAT might include a lower than otherwise possible immune response. A...
Tipo: Text
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00470/58122/60546.pdf