Consulta: creatorFacets:"RONCAGLIOLO,MANUEL"
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Data/hora: 04/06/2024 02:29:55

Dysmyelination, demyelination and reactive astrogliosis in the optic nerve of the taiep rat
Provedor de dados: 48
Autores: KRSULOVIC,JUAN; COUVE,EDUARDO; RONCAGLIOLO,MANUEL.
Taiep is an autosomal recessive mutant rat that shows a highly hypomyelinated central nervous system (CNS). Oligodendrocytes accumulate microtubules (MTs) in association with endoplasmic reticulum (ER) membranes forming MT-ER complexes. The microtubular defect in oligodendrocytes, the abnormal formation of CNS myelin and the astrocytic reaction were characterized by immunocytochemical and ultrastructural methods during the first year of life. Optic nerves of both control and taiep rats were processed by the immunoperoxidase method using antibodies against tubulin, myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP). Taiep oligodendrocytes are strongly immunoreactive against tubulin, indicative of a significant accumulation of...
Tipo: Journal article
Palavras-chave: Myelin mutant; Taiep rat; Optic nerve; Dysmyelination; Demyelination; Astrogliosis.
Ano: 1999
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97601999000400005