Consulta: creatorFacets:"Ramirez,J.A.F."
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Hyperhomocystinemia in patients with coronary artery disease
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Faria-Neto,J.R.; Chagas,A.C.P.; Bydlowski,S.P.; Lemos Neto,P.A.; Chamone,D.A.; Ramirez,J.A.F.; da Luz,P.L.
Hyperhomocystinemia has been related to an increased risk of cardiovascular disease in several studies. The C677T polymorphism for the gene that encodes the methylenetetrahydrofolate reductase enzyme (MTHFR) and low plasma folate levels are common causes of hyperhomocystinemia. Due to differences in nutritional patterns and genetic background among different countries, we evaluated the role of hyperhomocystinemia as a coronary artery disease (CAD) risk factor in a Brazilian population. The relation between homocysteine (Hcy) and the extent of CAD, measured by an angiographic score, was determined. A total of 236 patients referred for coronary angiography for clinical reasons were included. CAD was found in 148 (62.7%) patients and 88 subjects had normal or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hyperhomocystinemia; Homocysteine; Methylenetetrahydrofolate reductase; Atherosclerosis; Folic acid deficiency.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400005