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Adrenergic receptor β3 is involved in the memory consolidation process in mice
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Souza-Braga,P.; Lorena,F.B.; Nascimento,B.P.P.; Marcelino,C.P.; Ravache,T.T.; Ricci,E.; Bernardi,M.M.; Ribeiro,M.O.
Attention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharmacological studies suggest that memory acquisition depends on the action of both the β3 (β3-AR) and β2 (β2-AR) receptor subtypes. However, the use of animal models with specific knockout for the β3-AR receptor only (β3-ARKO) allows researchers to more accurately assess its role in memory formation processes. In the present study, we evaluated short- and long-term memory acquisition capacity in β3-ARKO mice and wild-type mice at approximately 60 days of age. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adrenergic receptors; Memory; GLUT3; Β3-AR.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000607