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VP22 herpes simplex virus protein can transduce proteins into stem cells
Provedor de dados: 56
Autores: Gabanyi,I.; Lojudice,F.H.; Kossugue,P.M.; Rebelato,E.; Demasi,M.A.; Sogayar,M.C.
The type I herpes simplex virus VP22 tegument protein is abundant and well known for its ability to translocate proteins from one cell to the other. In spite of some reports questioning its ability to translocate proteins by attributing the results observed to fixation artifacts or simple attachment to the cell membrane, VP22 has been used to deliver several proteins into different cell types, triggering the expected cell response. However, the question of the ability of VP22 to enter stem cells has not been addressed. We investigated whether VP22 could be used as a tool to be applied in stem cell research and differentiation due to its capacity to internalize other proteins without altering the cell genome. We generated a VP22.eGFP construct to evaluate...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: VP22 protein delivery; Protein transducing domain; EGFP; Stem cells transduction; Cell differentiation.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200121