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Melanoma, ancestry and MC1R variants in the Uruguayan admixed population
Provedor de dados: 46
Autores: Hochmann,J; Cappetta,M; Pérez,J; Colistro,V; Nicolleti,S; Larre Borges,A; Ribas,G; Martínez Asuaga,M; Bertoni,B.
Malignant melanoma (MM) is the most dangerous type of skin cancer and the main cause of death produced by skin diseases. In Uruguay, the incidence rate is 3.8/100,000, one of the highest in Latin America. We analyzed the contribution of ancestry and MC1R as a candidate gene for sporadic melanoma in Uruguay. Our objective wasto investigate the possible associations between ancestry and the MC1R gene with sporadic melanoma in the Uruguayan population. To that end, one hundred patients with sporadic MM and 107 controls were recruited. Phenotypic factors and lifestyle were evaluated as risk factors. At the same time, we analyzed fiveancestry informative markers, the MC1R variants (R151, R160 and D294H) and five tag-SNPs. Phototype, atypical nevi, sunburns and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Melanoma susceptibility; Melanocortin 1 Receptor gene; Red Hair Color (RHC) mutations; Ancestry; Uruguayan population.
Ano: 2016
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332016000100001