Consulta: creatorFacets:"Roche, Benjamin"
Registros recuperados: 2
Data/hora: 08/06/2024 18:07:52

Personal history of infections and immunotherapy: unexpected links and possible therapeutic opportunities
Provedor de dados: 5
Autores: Jacqueline, Camille; Bonnefoy, Nathalie; Charriere, Guillaume; Thomas, Frederic; Roche, Benjamin.
The recent breakthroughs in the understanding of tumor immune biology have given rise to a new generation of immunotherapies, harnessing the immune system to eliminate tumors. As the typology and frequency of encountered infections are susceptible to shape the immune system, it could also impact the efficiency of immunotherapy. In this review, we report evidences for an indirect link between personal history of infection and different strategies of immunotherapy. In the current context of interest rise for personalized medicine, we discuss the potential medical applications of considering personal history of infection to design immunotherapeutic strategies.
Tipo: Text
Palavras-chave: Immunotherapy; Infections; Personalized medicine; Cancer vaccine; Immune checkpoints; Adoptive cell transfer.
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00437/54865/57788.pdf

Is adaptive therapy natural?
Provedor de dados: 5
Autores: Thomas, Frederic; Donnadieu, Emmanuel; Charriere, Guillaume; Jacqueline, Camille; Tasiemski, Aurelie; Pujol, Pascal; Renaud, Francois; Roche, Benjamin; Hamede, Rodrigo; Brown, Joel; Gatenby, Robert; Ujvari, Beata.
Research suggests that progression-free survival can be prolonged by integrating evolutionary principles into clinical cancer treatment protocols. The goal is to prevent or slow the proliferation of resistant malignant cell populations. The logic behind this therapy relies on ecological and evolutionary processes. These same processes would be available to natural selection in decreasing the probability of an organism's death due to cancer. We propose that organisms' anticancer adaptions include not only ones for preventing cancer but also ones for directing and retarding the evolution of life-threatening cancer cells. We term this last strategy natural adaptive therapy (NAT). The body's NAT might include a lower than otherwise possible immune response. A...
Tipo: Text
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00470/58122/60546.pdf