Consulta: creatorFacets:"Rodrigues,E.B."
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Quantitative evaluation of experimental choroidal neovascularization by confocal scanning laser ophthalmoscopy: fluorescein angiogram parallels heparan sulfate proteoglycan expression
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Regatieri,C.V.; Dreyfuss,J.L.; Melo,G.B.; Lavinsky,D.; Hossaka,S.K.; Rodrigues,E.B.; Farah,M.E.; Maia,M.; Nader,H.B.
The objective of the present study was to develop a quantitative method to evaluate laser-induced choroidal neovascularization (CNV) in a rat model using Heidelberg Retina Angiograph 2 (HRA2) imaging. The expression of two heparan sulfate proteoglycans (HSPG) related to inflammation and angiogenesis was also investigated. CNV lesions were induced with argon laser in 21 heterozygous Zucker rats and after three weeks a fluorescein angiogram and autofluorescence exams were performed using HRA2. The area and greatest linear dimension were measured by two observers not aware of the protocol. Bland-Altman plots showed agreement between the observers, suggesting that the technique was reproducible. After fluorescein angiogram, HSPG (perlecan and syndecan-4) were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Choroidal neovascularization; Fluorescein angiogram; Proteoglycans; Angiogenesis; Confocal scanning laser ophthalmoscope.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700004