Consulta: creatorFacets:"Rodrigues,Marcela Marcondes Pinto"
Registros recuperados: 3
Data/hora: 10/06/2024 05:30:30

Evaluation of cell proliferation and apoptosis in placentas of rats with severe diabetes
Provedor de dados: 52
Autores: Rudge,Marilza Vieira Cunha; Costa,Elaine; Barbisan,Luis Fernando; Damasceno,Débora Cristina; Bueno,Aline; Saito,Felipe Hiroshi; Calderon,Iracema Mattos Paranhos; Rodrigues,Marcela Marcondes Pinto.
The aim of this work was to analyze the cell proliferation and apoptosis indexes on the 18th and 21st days of pregnancy of diabetic rats and to correlate with maternal glycemia and perinatal outcomes. Placentas from 20 Wistar rats were collected and divided into four experimental groups: control and diabetic of 18 and 21 days of pregnancy. The cell proliferation was analyzed using the PCNA expression and apoptosis by the TUNEL method. It was observed that PCNA and TUNEL indexes decreased from day 18 to 21 of pregnancy in the placentas of diabetic rats and these values were lower than control groups. Diabetic dams presented higher percentage of small for pregnancy age (SPA) fetuses. However, there was no difference between the PCNA and TUNEL indexes in SPA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diabetes; Cell proliferation; Apoptosis; Placenta; Rat; IUGR.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200009

Caracterização histomorfológica da atrofia inflamatória proliferativa na próstata canina
Provedor de dados: 65
Autores: Toledo,Denise Caroline; Faleiro,Mariana Batista Rodrigues; Rodrigues,Marcela Marcondes Pinto; Di Santis,Giovana Wingeter; Amorim,Renée Laufer; Moura,Veridiana Maria Brianezi Dignani de.
A atrofia inflamatória proliferativa (PIA) é uma lesão prostática pré-maligna de grande ocorrência na próstata humana e, mais recentemente, também observada em cães. Esta pesquisa teve por objetivo verificar os aspectos histomorfológicos da PIA na próstata canina. Foram utilizadas 43 próstatas de cães adultos, de várias raças e portes, e com histórico ou não de doença prostática. Os focos de PIA apresentaram epitélio displásico, formado por ácinos atróficos e com mais de uma camada de células de morfologia atípica, especialmente anisocitose, anisocariose, citoplasma reduzido, núcleo volumoso e com nucléolo evidente. As alterações epiteliais eram sempre acompanhadas de infiltrado inflamatório intersticial periacinar predominantemente linfocitário. Foi...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cão; PIA; Displasia prostática.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782010000600021

Matrix metalloproteinases 2 and 9 expression in canine normal prostate and with proliferative disorders
Provedor de dados: 65
Autores: Faleiro,Mariana Batista Rodrigues; Croce,Giuliana Brasil; Toledo,Denise Caroline; Rodrigues,Marcela Marcondes Pinto; Batista,Aline Carvalho; Damasceno,Adilson Donizeti; Brito,Luiz Augusto Batista; Amorim,Renée Laufer; Moura,Veridiana Maria Brianezi Dignani de.
In this study the expression of metalloproteinases 2 (MMP-2) and 9 (MMP-9) in canine normal prostates and with proliferative disorders was evaluated to verify the role of these enzymes in extracellular matrix remodeling (ECM) and in the tissue invasion process. A total of 355 prostatic samples were obtained, from which 36 (10.1%) were normal prostates, 46 (13.0%) with benign prostatic hyperplasia (BPH), 128 (36.1%) with proliferative inflammatory atrophy (PIA), 74 (20.8%) with prostatic intraepithelial neoplasia (PIN), and 71 (20.0%) with prostatic carcinoma (PC). Difference in cytoplasmic immunohistochemical staining of MMP-2 and MMP-9 between acinar epithelium and periacinar stroma was found regarding the different diagnosis. The correlation between...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dog; Gelatinases; Benign prostatic hyperplasia; Proliferative inflammatory atrophy; Prostatic intraepithelial neoplasia; Prostatic carcinoma.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782013000600015