Consulta: creatorFacets:"Rubio, Tristan"
Registros recuperados: 3
Data/hora: 01/06/2024 19:06:25

Species-specific mechanisms of cytotoxicity toward immune cells determine the successful outcome of Vibrio infections
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Rubio, Tristan; Oyanedel, Daniel; Labreuche, Yannick; Toulza, Eve; Luo, Xing; Bruto, Maxime; Chaparro, Cristian; Torres, Marta; De Lorgeril, Julien; Haffner, Philippe; Vidal-dupiol, Jeremie; Lagorce, Arnaud; Petton, Bruno; Mitta, Guillaume; Jacq, Annick; Le Roux, Frederique; Charriere, Guillaume; Destoumieux-garzon, Delphine.
Vibrio species cause infectious diseases in humans and animals, but they can also live as commensals within their host tissues. How Vibrio subverts the host defenses to mount a successful infection remains poorly understood, and this knowledge is critical for predicting and managing disease. Here, we have investigated the cellular and molecular mechanisms underpinning infection and colonization of 2 virulent Vibrio species in an ecologically relevant host model, oyster, to study interactions with marine Vibrio species. All Vibrio strains were recognized by the immune system, but only nonvirulent strains were controlled. We showed that virulent strains were cytotoxic to hemocytes, oyster immune cells. By analyzing host and bacterial transcriptional...
Tipo: Text
Palavras-chave: T6SS; Toxin; Dual RNA-seq; Cytolysis; Pathogenesis.
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00507/61837/65900.pdf

Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: De Lorgeril, Julien; Lucasson, Aude; Petton, Bruno; Toulza, Eve; Montagnani, Caroline; Clerissi, Camille; Vidal-dupiol, Jeremie; Chaparro, Cristian; Galinier, Richard; Escoubas, Jean Michel; Haffner, Philippe; Degremont, Lionel; Charriere, Guillaume; Lafont, Maxime; Delort, Abigail; Vergnes, Agnes; Chiarello, Marlene; Faury, Nicole; Rubio, Tristan; Leroy, Marc; Perignon, Adeline; Regler, Denis; Morga, Benjamin; Alunno-bruscia, Marianne; Boudry, Pierre; Le Roux, Frederique; Destoumieux-garzon, Delphine; Gueguen, Yannick; Mitta, Guillaume.
Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly in fluenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial...
Tipo: Text
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00461/57234/59228.pdf

Vibrio splendidus   O-antigen structure: A trade-off between virulence to oysters and resistance to grazers
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Oyanedel, Daniel; Labreuche, Yannick; Bruto, Maxime; Amraoui, Hajar; Robino, Etienne; Haffner, Philippe; Rubio, Tristan; Charrière, Guillaume; Le Roux, Frederique; Destoumieux-garzón, Delphine.
A major debate in evolutionary biology is whether virulence is maintained as an adaptive trait and/or evolves to non‐virulence. In the environment, virulence traits of non‐obligatory parasites are subjected to diverse selective pressures and trade‐offs. Here we focus on a population of Vibrio splendidus that displays moderate virulence for oysters. A MARTX (Multifunctional‐autoprocessing repeats‐in‐toxin) and a type‐six secretion system (T6SS) were found to be necessary for virulence toward oysters, while a region (wbe) involved in O‐antigen synthesis is necessary for resistance to predation against amoebae. Gene inactivation within the wbe region had major consequences on the O‐antigen structure, conferring lower immunogenicity, competitive advantage and...
Tipo: Text
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00619/73070/72194.pdf