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Antiedematogenic activity of the indole derivative N-salicyloyltryptamine in animal models
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: SOUSA-NETO,BENEDITO P.; GOMES,BRUNO S.; CUNHA,FRANCISCO V.M.; ARCANJO,DANIEL D.R.; GUTIERREZ,STANLEY J.C.; SOUZA,MARIA F.V.; ALMEIDA,FERNANDA R.C.; OLIVEIRA,FRANCISCO A.
ABSTRACT The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. The potential NST-induced antiedematogenic activity was evaluated by carrageenan-induced paw edema in rats, as well as by dextran-, compound 48/80-, histamine-, serotonin-, capsaicine-, and prostaglandin E2-induced paw edema in mice. The effect of NST on compound 48/80-induced ex vivo mast cell degranulation on mice mesenteric bed was investigated. No death or alteration of behavioral parameters was observed after administration of NST (2000 mg/kg, i.p.)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anti-inflammatory agents; Edema; Indoles; Inflammation mediators; N-salicyloyltryptamine.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000100185