Consulta: creatorFacets:"SUGUI,Marina Mariko"
Registros recuperados: 2
Data/hora: 05/06/2024 16:58:45

Evaluation of antimutagenic and cytotoxic activity of skin secretion extract of Rhinella marina and Rhaebo guttatus (Anura, Bufonidae)
Provedor de dados: 36
Autores: OLIVEIRA,Angellica Fernandes de; CASTOLDI,Lindsey; VIEIRA JUNIOR,Gerardo Magela; MONÇÃO FILHO,Evaldo dos Santos; CHAVES,Mariana Helena; RODRIGUES,Domingos de Jesus; SUGUI,Marina Mariko.
ABSTRACT The skin secretion from toads of the Bufonidae family has great potential in the search for new active compounds to be used as drug candidates in treating some diseases, among them cancer. In this context, this study aimed to evaluate the cytotoxic and antimutagenic activity of the parotoid gland secretion extracts of Rhinella marina and Rhaebo guttatus, as well as biochemically analyze transaminases and serum creatinine for liver and renal damage, respectively. Cytotoxicity was performed by the colorimetric method based on MTT (3- [4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium bromide) with different concentrations of the extracts in Walker or splenic tumor cell cultures from rats and mice. The micronucleus test was performed with male...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Genotoxicity; Bioprospecting; Micronuclei; Chemoprevention.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672019000200145

First phytochemical and biological study of the ethanolic extract from leaves of Capirona decorticans (Rubiaceae)
Provedor de dados: 36
Autores: BARBOSA,Fernando Gomes; SUGUI,Marina Mariko; SINHORIN,Valéria Dornelles Gindri; BICUDO,Rogério de Campos; MOURA,Fernando Rafael de; SINHORIN,Adilson Paulo.
ABSTRACT Capirona decorticans (Rubiaceae) is popularly used to treat warts, wounds, mycoses and scabies, and is also a component of the Ayahuasca tea. Despite its popular use, the phytochemical and pharmacological research on this species is limited. Therefore, this work quantified phenolic compounds in the ethanolic extract (EE) and hydromethanolic fraction (FM) (406, 293 mgEAG g-1, respectively) from leaves of C. decorticans. We identified flavonoids by LC-MS/MS-MMR-ESI (apigenin, rutin, luteolin, miricetin, quercetin, quercetin-3-β-D-glucoside, quercetrin), and evaluated oxidative stress and mutagenic/antimutagenic effect of EE and FM through an in vivo experiment using Swiss mice and cyclophosphamide (CP) as an inducer of DNA damage and oxidative...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Oxidative stress; Cyclophosphamide; Genotoxicity; Phenolic compounds.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672018000400338