Consulta: creatorFacets:"Sala,Miguel A"
Registros recuperados: 5
Data/hora: 04/06/2024 03:33:45

PHENYTOIN ACTION IN THE LINGUAL MUCOSA OF RAT FETUSES: MORPHOMETRIC STUDY
Provedor de dados: 77
Autores: Siéssere,Selma; Semprini,Marisa; Lopes,Ruberval A; Azoubel,Reinaldo; Sala,Miguel A; Mattos,Maria G. C; Hallak Regalo,Simone Cecílio.
Phenytoin (diphenylhydantoin, dilantin) has been the chosen anti-convulsive for the treatment of sudden disorders since the late 1930's. Several epidemiological and clinical studies in human beings showed an increase in malformations in descendants of which mothers took phenytoin during gestation, such as cranio-facial development and growth abnormalities, distal phalangeal hypoplasia, and light or moderate mental deficiency. This work had the goal to study the lingual mucosa, under histopathological and morphometric standpoints, in rat fetuses which were given an intraperitonial injection, consisting of a unique dose of phenytoin (70 milligrams/kilogram of their weight). Being that, we included the examined material in paraffin, 6 micrometers thick, and...
Tipo: Journal article
Palavras-chave: Phenytoin; Lingual mucosa; Rat; Morphometry.
Ano: 2004
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200009

Estudio Morfológico e Histoquímico de las Glándulas Cefálicas de Bothrops alternatus (Ophidia, Viperidae)
Provedor de dados: 77
Autores: Parpinelli,Ana Carolina; Lopes,Ruberval A; Sala,Miguel A; Issa,João Paulo M; Lopes,Túlio Roberto V. P.
El objetivo del presente trabajo fue estudiar la histología de las glándulas cefálicas de la víbora de la cruz (Bothrops alternatus), identificar los tipos celulares y caracterizar histoquimicamente el producto de secreción. Con esta finalidad fueron usados ejemplares machos adultos de B. alternatus. Después del sacrificio, las glándulas cefálicas fueron fijadas en formol neutro al 10% e incluidas en parafina. Los cortes, de 6 µm de espesor, fueron teñidos con hematoxilina y eosina, tricrómico de Masson y con técnicas histoquímicas para identificación de mucopolisacáridos y proteínas. Los resultados histológicos demostraron que las glándulas linguales, de veneno y accesorias son de tipo tubular, las glándulas labiales y premaxilar son tubuloacinares y la...
Tipo: Journal article
Palavras-chave: Morfología; Histoquímica; Glándulas cefálicas; Bothrops alternatus.
Ano: 2013
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300041

MORPHOLOGICAL AND MORPHOMETRIC ALTERATIONS INDUCED BY VALPROIC ACID ON RAT FETUSES' MECKEL'S CARTILAGE, LINGUAL MUSCULATURE, AND SUBMANDIBULAR GLAND
Provedor de dados: 77
Autores: Siéssere,Selma; Semprini,Marisa; Lopes,Ruberval A; Sala,Miguel A; Mattos,Maria G. C.
Valproic acid, an antiepileptic drug, is a well-known teratogenic agent; its main target organ is the neural tube, though organ malformations have also been described. The aim of the present work was to analyze the effects of valproic acid on embryo/fetal oral structures: Meckel's cartilage, muscles of the tongue, and submandibular gland. Rats received a intraperitoneal injected of Valproic acid (300mg/Kg) on the 10th day of their gestation. Females were sacrificed on day 20 post coitus, and fetuses were examined. No gross malformations were observed. The following morphological alterations were observed: lower body and placental weight; shorter umbilical cord length; submandibular gland parenchyma less differentiated with larger cellular cord and terminal...
Tipo: Journal article
Palavras-chave: Valproic acid; Rat; Meckel's cartilage; Lingual musculature; Submandibular gland.
Ano: 2004
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200006

Estudio Morfológico, Morfométrico e Histoquímico de los Epitelios de Revestimiento y Glandular de la Lengua de la Rana Toro, Rana catesbeiana
Provedor de dados: 77
Autores: Guiraldelli,Michel Farchi; Lopes,Ruberval A; Sala,Miguel A; Lopes,Túlio Roberto V. P.
La superficie dorsal de la lengua de la rana toro, Rana catesbeiana, presenta un epitelio simple cilíndrico, constituido por células caliciformes y raras células ciliadas. El dorso de la lengua posee numerosas papilas filiformes y algunas fungiformes. Las primeras poseen un epitelio simple cilíndrico, con células secretoras, mientras que las segundas poseen en la región apical, un disco sensorial con epitelio estratificado cilíndrico, con células basales, periféricas, glandulares y receptoras. A lo largo del dorso de la lengua existen numerosas glándulas tubulares, que penetran en profundidad, entremezclándose con las fibras musculares. El epitelio glandular es simple cilíndrico, con células secretoras y de sostén. Las primeras son las únicas en la base de...
Tipo: Journal article
Palavras-chave: Lengua; Glándulas linguales; Morfometría; Histoquímica; Rana Toro; Rana catesbeiana.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100038

Action of Trivalent Chromium on Rat Liver Structure. Histometric and Haematological Studies
Provedor de dados: 77
Autores: Silva,Rogério Ferreira da; Lopes,Ruberval A; Sala,Miguel A; Vinha,Dionísio; Regalo,Simone C. H.; Souza,Ana Maria de; Gregório,Zita Maria de O.
The trace mineral trivalent chromium (Cr3+) is an essential nutrient involved in the regulation of carbohydrate, lipid and protein metabolism via an enhancement of insulin action. The present work had as objective to characterize histopathologically and histometrically the hepatic alterations of female Wistar rats, determined by the chromium III administration in drinking water. Adult rats received ration and drinking water ad libitum containing 300 or 500 mg/l chromium III during 4 months. Control animals received only water and ration. All animals were sacrificed by lethal dose of anesthetic. Samples of liver were fixed in 10% formalin for 24 h. Tissues for microscopical pathology were processed using standard procedures. Paraffin sections prepared at 6...
Tipo: Journal article
Palavras-chave: Liver; Rat; Chromium; Morphometry; Hematology.
Ano: 2006
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300014