Consulta: creatorFacets:"Sanches,L.R."
Registros recuperados: 1
Data/hora: 09/06/2024 17:39:26

Diagnostic accuracy of thromboelastometry and its correlation with the HPLC-MS/MS quantification test
Provedor de dados: 56
Autores: Aranda,V.F. de; Derogis,P.B.M.; Sanches,L.R.; Mangueira,C.L.P.; Katz,M.; Faulhaber,A.C.L.; Mendes,C.E.A.; Ferreira,C.E. dos Santos; França,C.N.; Guerra,J.C. de Campos.
The aim of the study was to evaluate the diagnostic accuracy of thromboelastometry for assessing rivaroxaban concentrations. The accuracy of thromboelastometry was compared with the high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method, which is the gold standard for drug plasma monitoring (the reference standard). Forty-six clinically stable patients were treated with 10, 15, or 20 mg of rivaroxaban once daily (OD group) or 15 mg twice a day (BID group) (no particular indication for treatment). Patient samples were collected 2 h after the use of the medication (peak) and 2 h before the next dose (trough). The rivaroxaban plasma concentrations were determined via HPLC-MS/MS, and thromboelastometry was performed using a ROTEM®...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anticoagulants; Blood coagulation; Plasma concentration; Rivaroxaban; Tandem mass spectrometry; Thromboelastometry.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000400603