Consulta: creatorFacets:"Schmidt,D."
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Participation of the GABAergic system in the anesthetic effect of Lippia alba (Mill.) N.E. Brown essential oil
Provedor de dados: 56
Autores: Heldwein,C.G.; Silva,L.L.; Reckziegel,P.; Barros,F.M.C.; Bürger,M.E.; Baldisserotto,B.; Mallmann,C.A.; Schmidt,D.; Caron,B.O.; Heinzmann,B.M.
The objective of this study was to identify the possible involvement of the GABAergic system in the anesthetic effect of Lippia alba essential oil (EO). We propose a new animal model using silver catfish (Rhamdia quelen) exposed to an anesthetic bath to study the mechanism of action of EO. To observe the induction and potentiation of the anesthetic effect of EO, juvenile silver catfish (9.30 ± 1.85 g; 10.15 ± 0.95 cm; N = 6) were exposed to various concentrations of L. alba EO in the presence or absence of diazepam [an agonist of high-affinity binding sites for benzodiazepinic (BDZ) sites coupled to the GABA A receptor complex]. In another experiment, fish (N = 6) were initially anesthetized with the EO and then transferred to an anesthetic-free aquarium...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: False-melissa; Silver catfish; Benzodiazepines; Flumazenil; GABA.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500009