Consulta: creatorFacets:"Selegatto,M.A."
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Data/hora: 09/06/2024 00:50:28

Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
Provedor de dados: 45
Autores: Souza,A.H.; Valadão,C.A.A.; Selegatto,M.A.; Almeida,R.M.; Macari,M.
The present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5µg.kg-1 body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onset and magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO may provide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kB mediated events, such as fever.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: LPS; Fever; DMSO; Rabbits.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016