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Potential effects of a low molecular weight Fucoidan extracted from brown algae on bone biomaterial osteoconductive properties
Provedor de dados: 5
Autores: Igondjo Tchen Changotade, S; Korb, G; Bassil, J; Barroukh, B; Willig, C; Colliec-jouault, Sylvia; Durand, Patrick; Godeau, G; Senni, K.
In this work we firstly tested the influence of low molecular weight fucoidan extracted from pheophicae cell wall on bidimensional cultured normal human osteoblasts behaviours. Secondly impregnation procedure with LMW fucoidan of bone biomaterial (Lubboc®) we explored in this bone extracellular matrix context its capabilities to support human osteoblastic behaviour in 3D culture. In bidimensionnal cultures we evidenced that: LMW fucoidan promotes human osteoblast proliferation, collagen type I expression and favours precocious alkaline phosphatase activity. Furthermore with LMW fucoidan von Kossa's staining was positive at 30 days and only positive at 45 days in absence of LMW fucoidan. In our three dimensional culture models with the biomaterial...
Tipo: Text
Palavras-chave: Heparan mimetics; Biomaterial; Bone; Osteoblast; Fucoidan.
Ano: 2008
URL: http://archimer.ifremer.fr/doc/2007/publication-2695.pdf