Consulta: creatorFacets:"Slavov,S.N."
Registros recuperados: 3
Data/hora: 02/06/2024 00:58:10

Late emergence of A594V and L595W mutations related to ganciclovir resistance in a patient with HCMV retinitis and long-term HIV progression
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Slavov,S.N.; Vilar,F.C.; Wagatsuma,V.M.D.; Santana,R.C.; Machado,A.A.; Fonseca,B.A.L. da; Kashima,S.; Covas,D.T.
The emergence of ganciclovir (GCV) resistance during the treatment of human cytomegalovirus (HCMV) infection is a serious clinical challenge, and is associated with high morbidity and mortality. In this case report, we describe the emergence of two consecutive mutations (A594V and L595W) related to GCV resistance in a patient with HCMV retinitis and long-term HIV progression after approximately 240 days of GCV use. Following the diagnosis of retinitis, the introduction of GCV did not result in viral load reduction. The detected mutations appeared late in the treatment, and we propose that other factors (high initial HCMV load, previous GCV exposure, low CD4+ cell count), in addition to the presence of resistance mutations, may have contributed to the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human cytomegalovirus; HCMV; Ganciclovir; Resistance; AIDS.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900777

The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Slavov,S.N.; Gimenes Teixeira,H.L.; Rego,E.M.
Micro-ribonucleic acids (microRNAs) are small molecules containing 20-23 nucleotides. Despite their small size, it is likely that almost every cellular process is regulated by them. Moreover, aberrant microRNA expression has been involved in the development of various diseases, including cancer. Although many data are available about the role of microRNAs in various lymphoproliferative disorders, their impact on the development of acute lymphoblastic leukemia of T-cell progenitors is largely unknown. In this review, we present recent information about how specific microRNAs are expressed and regulated during malignant T-lymphopoiesis and about their role during normal hematopoiesis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MicroRNAs; Gene expression; Leukemia; Acute lymphoblastic leukemia; T cells.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700003

Overview of Zika virus (ZIKV) infection in regards to the Brazilian epidemic
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Slavov,S.N.; Otaguiri,K.K.; Kashima,S.; Covas,D.T.
Zika virus (ZIKV), a mosquito-borne flavivirus, belongs to the Flaviviridae family, genus Flavivirus. ZIKV was initially isolated in 1947 from a sentinel monkey in the Zika forest, Uganda. Little clinical importance was attributed to ZIKV, once only few symptomatic cases were reported in some African and Southeast Asiatic countries. This situation changed in 2007, when a large outbreak was registered on the Yap Island, Micronesia, caused by the Asian ZIKV lineage. Between 2013 and 2014, ZIKV spread explosively and caused many outbreaks in different islands of the Southern Pacific Ocean and in 2015 autochthonous transmission was reported in Brazil. Currently, Brazil is the country with the highest number of ZIKV-positive cases in Latin America. Moreover,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Zika virus; ZIKV; Transmission; Epidemiology; Congenital infection; Brazil.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000500201