Consulta: creatorFacets:"Sugayama,S.M.M."
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Data/hora: 10/06/2024 16:25:48

Evaluation of the immune humoral response of Brazilian patients with Rubinstein-Taybi syndrome
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Sugayama,S.M.M.; Arslanian,C.; Sales,M.M.; Carneiro-Sampaio,M.
Rubinstein-Taybi syndrome (RTS) is a rare developmental disorder characterized by craniofacial dysmorphisms, broad thumbs and toes, mental and growth deficiency, and recurrent respiratory infections. RTS has been associated with CREBBP gene mutations, but EP300 gene mutations have recently been reported in 6 individuals. In the present study, the humoral immune response in 16 RTS patients with recurrent respiratory infections of possible bacterial etiology was evaluated. No significant differences between patients and 16 healthy controls were detected to explain the high susceptibility to respiratory infections: normal or elevated serum immunoglobulin levels, normal salivary IgA levels, and a good antibody response to both polysaccharide and protein...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rubinstein-Taybi syndrome; High IgM levels; B lymphocyte; Antibody response.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200011