Consulta: creatorFacets:"Tritton,T.R."
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Data/hora: 09/06/2024 08:24:48

Collateral methotrexate resistance in cisplatin-selected murine leukemia cells
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Bhushan,A.; Hacker,M.P.; Tritton,T.R.
Resistance to anticancer drugs is a major cause of failure of many therapeutic protocols. A variety of mechanisms have been proposed to explain this phenomenon. The exact mechanism depends upon the drug of interest as well as the tumor type treated. While studying a cell line selected for its resistance to cisplatin we noted that the cells expressed a &amp;gt;25,000-fold collateral resistance to methotrexate. Given the magnitude of this resistance we elected to investigate this intriguing collateral resistance. From a series of investigations we have identified an alteration in a membrane protein of the resistant cell as compared to the sensitive cells that could be the primary mechanism of resistance. Our studies reviewed here indicate decreased tyrosine...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Methotrexate transport; Resistance; Cisplatin; Leukemia; Phosphorylation.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700005