Consulta: creatorFacets:"Tufik,S."
Registros recuperados: 37
Data/hora: 04/06/2024 02:11:31

Sleep disorder or simple sleep ontogeny? Tendency for morningness is associated with worse sleep quality in the elderly
Provedor de dados: 56
Autores: Barbosa,A.A.; Miguel,M.A.L.; Tufik,S.; Sabino,F.C.; Cendoroglo,M.S.; Pedrazzoli,M.
The objective of this study was to evaluate the alterations in sleep and circadian parameters during the aging process. The study sample comprises volunteers older than 18 up to 90 years of age that answered the Pittsburgh Sleep Quality Index (PSQI) and the Horne and Östberg circadian preference questionnaire. We observed that the shift to morningness with increasing age is associated with a significant worsening in sleep quality. We discuss that this sleep profile characterized by morningness and worse sleep quality observed in elderly, when compared to younger people, reflects not necessarily a pathological state, but an expected profile for this age group.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Elderly; Sleep quality; Circadian rhythmicity; Chronotype; Sleep ontogeny.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000606

Delta sleep instability in children with chronic arthritis
Provedor de dados: 56
Autores: Lopes,M.C.; Guilleminault,C.; Rosa,A.; Passarelli,C.; Roizenblatt,S.; Tufik,S.
The objective of the present study was to evaluate the expression of a cyclic alternating pattern (CAP) in slow wave sleep (SWS) in children with the well-defined chronic syndrome juvenile idiopathic arthritis (JIA). Twelve patients (9-17 years of age), 7 girls, with JIA were compared to matched controls by age, pubertal stage and gender. After one night of habituation in the sleep laboratory, sleep measurements were obtained by standard polysomnography with conventional sleep scoring and additional CAP analyses. The sleep parameters of the JIA and control groups were similar for sleep efficiency (91.1 ± 6.7 vs 95.8 ± 4.0), sleep stage in minutes: stage 1 (16.8 ± 8.5 vs 17.8 ± 4.0), stage 2 (251.9 ± 41 vs 262.8 ± 38.1), stage 3 (17.0 ± 6.0 vs 15.1 ± 5.7),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Children; Chronic-arthritis; Cyclic alternating pattern; Sleep fragmentation.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001000018

Participation of the cholinergic system in the ethanol-induced suppression of paradoxical sleep in rats
Provedor de dados: 56
Autores: Papale,L.A.; Andersen,M.L.; Perry,J.C.; Tufik,S.
Sleep disturbance is among the many consequences of ethanol abuse in both humans and rodents. Ethanol consumption can reduce REM or paradoxical sleep (PS) in humans and rats, respectively. The first aim of this study was to develop an animal model of ethanol-induced PS suppression. This model administered intragastrically (by gavage) to male Wistar rats (3 months old, 200-250 g) 0.5 to 3.5 g/kg ethanol. The 3.5 g/kg dose of ethanol suppressed the PS stage compared with the vehicle group (distilled water) during the first 2-h interval (0-2 h; 1.3 vs 10.2; P &lt; 0.001). The second aim of this study was to investigate the mechanisms by which ethanol suppresses PS. We examined the effects of cholinergic drug pretreatment. The cholinergic system was chosen...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cholinergic; Atropine; Pilocarpine; Ethanol; Paradoxical sleep; Electroencephalography.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900007

Different stress modalities result in distinct steroid hormone responses by male rats
Provedor de dados: 56
Autores: Andersen,M.L.; Bignotto,M.; Machado,R.B.; Tufik,S.
Since both paradoxical sleep deprivation (PSD) and stress alter male reproductive function, the purpose of the present study was to examine the influence of PSD and other stressors (restraint, electrical footshock, cold and forced swimming, N = 10 per group) on steroid hormones in adult Wistar male rats. Rats were submitted to chronic stress for four days. The stressors (footshock, cold and forced swimming) were applied twice a day, for periods of 1 h at 9:00 and 16:00 h. Restrained animals were maintained in plastic cylinders for 22 h/day whereas PSD was continuous. Hormone determination was measured by chemiluminescent enzyme immunoassay (testosterone), competitive immunoassay (progesterone) and by radioimmunoassay (corticosterone, estradiol, estrone)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Paradoxical sleep deprivation; Stress; Testosterone; Progesterone; Estrogen; Corticosterone.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600003

Sleep habits and complaints of adults in the city of São Paulo, Brazil, in 1987 and 1995
Provedor de dados: 56
Autores: Pires,M.L.N.; Benedito-Silva,A.A.; Mello,M.T.; Del Giglio,S.; Pompeia,C.; Tufik,S.
This study compares the prevalence of complaints of insomnia, excessive diurnal sleepiness, parasomnias, and sleep habits of the adult population in the city of São Paulo, Brazil, estimated in surveys carried out in 1987 and 1995. Representative samples of 1000 adult residents per survey were interviewed using a validated structured sleep questionnaire, the "UNIFESP Sleep Questionnaire". Difficulty maintaining sleep, difficulty initiating sleep and early morning awakening, occurring at least three times a week, were reported in 1987 and 1995, by 15.8/27.6, 13.9/19.1, and 10.6/14.2% of the interviewees, respectively, significantly increasing throughout time. These sleep problems were more often found among women. Frequencies of excessive diurnal sleepiness...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep; Sleep disorders; Insomnia; Diurnal sleepiness; Parasomnias; Epidemiology; Sleep habits.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100011

Effect of sildenafil (Viagra®) on the genital reflexes of paradoxical sleep-deprived male rats
Provedor de dados: 56
Autores: Andersen,M.L.; Bignotto,M.; Tufik,S.
Since there is evidence that paradoxical sleep deprivation (PSD) elicits penile erection (PE) and ejaculation (EJ), and that the erectile response of rats is mediated by nitric oxide, the present study sought to extend the latter finding by assessing the effects of sildenafil on the genital reflexes of male Wistar rats subjected to PSD. We also determined the influence of sildenafil on hormone concentrations. In the first experiment, sildenafil at doses ranging from 0.08 to 0.32 mg/kg was administered intraperitoneally to rats that had been deprived of sleep for 4 days and to home cage controls (N = 8-10/group). The frequency of PE and EJ was measured for 60 min. PSD alone induced PE in 50% of the animals; however, a single injection of sildenafil did not...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Paradoxical sleep deprivation; Sildenafil; Genital reflexes; Dopamine; Testosterone; Progesterone.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100008

Effects of type of physical exercise and leisure activities on the depression scores of obese Brazilian adolescent girls
Provedor de dados: 56
Autores: Stella,S.G.; Vilar,A.P.; Lacroix,C.; Fisberg,M.; Santos,R.F.; Mello,M.T.; Tufik,S.
Several studies have indicated that depressive states may lead to hypokinesia with diminished metabolic rate and energy use. Hypokinesia associated with certain eating behaviors may lead to an unfavorable energy balance that can contribute to the emergence and prevalence of obesity among children and adults. The purpose of the present study was to examine the possibility of reducing depression inventory scores in female adolescents with third-degree obesity while testing the effectiveness of different exercise programs in reducing anxiety and depression scores. The sample consisted of 40 female subjects (mean age 16 ± 1.56 years) divided into 4 groups (aerobic training, anaerobic training, leisure activities, and control). Subjects had a body mass index of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adolescents; Physical exercise; Leisure activity; Obesity.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100017

Resistance exercise improves hippocampus-dependent memory
Provedor de dados: 56
Autores: Cassilhas,R.C.; Lee,K.S.; Venâncio,D.P.; Oliveira,M.G.M.; Tufik,S.; Mello,M.T.
It has been demonstrated that resistance exercise improves cognitive functions in humans. Thus, an animal model that mimics this phenomenon can be an important tool for studying the underlying neurophysiological mechanisms. Here, we tested if an animal model for resistance exercise was able to improve the performance in a hippocampus-dependent memory task. In addition, we also evaluated the level of insulin-like growth factor 1/insulin growth factor receptor (IGF-1/IGF-1R), which plays pleiotropic roles in the nervous system. Adult male Wistar rats were divided into three groups (N = 10 for each group): control, SHAM, and resistance exercise (RES). The RES group was submitted to 8 weeks of progressive resistance exercise in a vertical ladder apparatus,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Physical exercise; Passive avoidance; Insulin-like growth factor 1; Resistance training; Hippocampus; Memory.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200015

Sleep pattern and learning in knockdown mice with reduced cholinergic neurotransmission
Provedor de dados: 56
Autores: Queiroz,C.M.; Tiba,P.A.; Moreira,K.M.; Guidine,P.A.M.; Rezende,G.H.S.; Moraes,M.F.D.; Prado,M.A.M.; Prado,V.F.; Tufik,S.; Mello,L.E.
Impaired cholinergic neurotransmission can affect memory formation and influence sleep-wake cycles (SWC). In the present study, we describe the SWC in mice with a deficient vesicular acetylcholine transporter (VAChT) system, previously characterized as presenting reduced acetylcholine release and cognitive and behavioral dysfunctions. Continuous, chronic ECoG and EMG recordings were used to evaluate the SWC pattern during light and dark phases in VAChT knockdown heterozygous (VAChT-KDHET, n=7) and wild-type (WT, n=7) mice. SWC were evaluated for sleep efficiency, total amount and mean duration of slow-wave, intermediate and paradoxical sleep, as well as the number of awakenings from sleep. After recording SWC, contextual fear-conditioning tests were used...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep-wake cycle; Intermediate sleep; Acetylcholine; Contextual fear conditioning; Memory; Neurodegenerative disorders.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000844

Relationship between Brazilian airline pilot errors and time of day
Provedor de dados: 56
Autores: de Mello,M.T.; Esteves,A.M.; Pires,M.L.N.; Santos,D.C.; Bittencourt,L.R.A.; Silva,R.S.; Tufik,S.
Flight safety is one of the most important and frequently discussed issues in aviation. Recent accident inquiries have raised questions as to how the work of flight crews is organized and the extent to which these conditions may have been contributing factors to accidents. Fatigue is based on physiologic limitations, which are reflected in performance deficits. The purpose of the present study was to provide an analysis of the periods of the day in which pilots working for a commercial airline presented major errors. Errors made by 515 captains and 472 copilots were analyzed using data from flight operation quality assurance systems. To analyze the times of day (shifts) during which incidents occurred, we divided the light-dark cycle (24:00) in four...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Airline pilot errors; Circadian rhythm.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200014

Neuroethologic differences in sleep deprivation induced by the single- and multiple-platform methods
Provedor de dados: 56
Autores: Medeiros,R.; Lenneberg-Hoshino,C.; Hoshino,K.; Tufik,S.
It has been proposed that the multiple-platform method (MP) for desynchronized sleep (DS) deprivation eliminates the stress induced by social isolation and by the restriction of locomotion in the single-platform (SP) method. MP, however, induces a higher increase in plasma corticosterone and ACTH levels than SP. Since deprivation is of heuristic value to identify the functional role of this state of sleep, the objective of the present study was to determine the behavioral differences exhibited by rats during sleep deprivation induced by these two methods. All behavioral patterns exhibited by a group of 7 albino male Wistar rats submitted to 4 days of sleep deprivation by the MP method (15 platforms, spaced 150 mm apart) and by 7 other rats submitted to...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Sleep deprivation methods; Stress; Social interactions; Group crowding effects.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000500012

A link between sleep loss, glucose metabolism and adipokines
Provedor de dados: 56
Autores: Padilha,H.G.; Crispim,C.A.; Zimberg,I.Z.; De-Souza,D.A.; Waterhouse,J.; Tufik,S.; de-Mello,M.T.
The present review evaluates the role of sleep and its alteration in triggering problems of glucose metabolism and the possible involvement of adipokines in this process. A reduction in the amount of time spent sleeping has become an endemic condition in modern society, and a search of the current literature has found important associations between sleep loss and alterations of nutritional and metabolic contexts. Studies suggest that sleep loss is associated with problems in glucose metabolism and a higher risk for the development of insulin resistance and type 2 diabetes mellitus. The mechanism involved may be associated with the decreased efficacy of regulation of the hypothalamus-pituitary-adrenal axis by negative feedback mechanisms in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Glucose metabolism; Insulin resistance; Sleep loss; Adipokines; Type 2 diabetes mellitus; Inflammatory status.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001000003

Gastroesophageal reflux episodes in asthmatic patients and their temporal relation with sleep architecture
Provedor de dados: 56
Autores: Mello-Fujita,L.; Roizenblat,S.; Frison.,C.R.; Rodrigues Junior,L.; Garbuio,S.; Tufik,S.; Bittencourt,L.R.A.
Gastroesophageal reflux (GER) is common in asthma patients and can contribute to sleep disruption. The aim of the present study was to determine the time-related distribution of GER events together with their impact on sleep in asthmatic subjects with GER disease symptoms. The inclusion criteria were: 18-65 years, controlled moderate to severe asthma and GER-compatible clinical evidence. The exclusion criteria were: chronic obstructive lung disease, smoking, infections of the upper airways, use of oral corticosteroids, other co-morbidities, pregnancy, sleep-related disorders, night-time shift work, and the use of substances with impact on sleep. Asthmatic patients with nocturnal symptoms were excluded. All-night polysomnography and esophageal pH monitoring...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Asthma; Gastroesophageal reflux; Polysomnography; Sleep.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200012

Sleep, ageing and night work
Provedor de dados: 56
Autores: Pires,M.L.N.; Teixeira,C.W.; Esteves,A.M.; Bittencourt,L.R.A.; Silva,R.S.; Santos,R.F.; Tufik,S.; Mello,M.T.
Studies have shown that the frequency or worsening of sleep disorders tends to increase with age and that the ability to perform circadian adjustments tends to decrease in individuals who work the night shift. This condition can cause consequences such as excessive sleepiness, which are often a factor in accidents that occur at work. The present study investigated the effects of age on the daytime and nighttime sleep patterns using polysomnography (PSG) of long-haul bus drivers working fixed night or day shifts. A total of 124 drivers, free of sleep disorders and grouped according to age (&lt;45 years, N = 85, and ≥45 years, N = 39) and PSG timing (daytime (D) PSG, N = 60; nighttime (N) PSG, N = 64) participated in the study. We observed a significant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep; Shift work; Night work; Aging; Polysomnography; REM; Slow wave sleep (SWS).
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000900011

Comparison of AutoSetä and polysomnography for the detection of apnea-hypopnea events
Provedor de dados: 56
Autores: Bagnato,M.C.; Nery,L.E.; Moura,S.M.T.; Bittencourt,L.R.A.; Tufik,S.
The use of the flow vs time relationship obtained with the nasal prongs of the AutoSetä (AS) system (diagnosis mode) has been proposed to detect apneas and hypopneas in patients with reasonable nasal patency. Our aim was to compare the accuracy of AS to that of a computerized polysomnographic (PSG) system. The study was conducted on 56 individuals (45 men) with clinical characteristics of obstructive sleep apnea (OSA). Their mean (± SD) age was 44.6 ± 12 years and their body mass index was 31.3 ± 7 kg/m2. Data were submitted to parametric analysis to determine the agreement between methods and the intraclass correlation coefficient was calculated. The Student t-test and Bland and Altman plots were also used. Twelve patients had an apnea-hypopnea index...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Obstructive sleep apnea; Polysomnography; Computerized diagnostic system.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000500005

Paradoxical sleep deprivation increases plasma endothelin levels
Provedor de dados: 56
Autores: Palma,B.D.; Gabriel Jr.,A.; Bignotto,M.; Tufik,S.
The endothelins (ET-1, 2 and 3) constitute a family of 21 amino acid peptides with potent biological activities. ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely related to the pathogenesis of arterial hypertension as well as to obstructive sleep apnea (OSA). OSA patients exhibit repetitive episodes of apnea and hypopnea that result in hypoxia and consecutive arousals. These patients are chronically sleep deprived, which may aggravate the hypertensive features, since literature data show that sleep deprivation results in hypertension both in humans and in animals. Based on the reported relationship between ET-1, hypertension and sleep deprivation consequences, the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Endothelin; Sleep deprivation; Rat; Hypertension.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100011

Sleep deprivation reduces the lymphocyte count in a non-obese mouse model of type 1 diabetes mellitus
Provedor de dados: 56
Autores: Ruiz,F.S.; Andersen,M.L.; Zager,A.; Martins,R.C.S.; Tufik,S.
The objective of the present study was to determine whether sleep deprivation (SD) would promote changes in lymphocyte numbers in a type 1 diabetes model (non-obese diabetic, NOD, mouse strain) and to determine whether SD would affect female and male NOD compared to Swiss mice. The number of lymphocytes in peripheral blood after 24 and 96 h of SD (by multiple platform method) or equivalent period of time in home-cage controls was examined prior to the onset of diabetes. SD for 96 h significantly reduced lymphocytes in male Swiss mice compared to control (8.6 ± 2.1 vs 4.1 ± 0.7 10³/µL; P &lt; 0.02). In male NOD animals, 24- and 96-h SD caused a significant decrease of lymphocytes compared to control (4.4 ± 0.3 vs 1.6 ± 0.5; P &lt; 0.001 and 4.4 ± 0.3 vs 0.9...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Sleep deprivation; Stress; Lymphopenia; Diabetes; Non-obese diabetic mouse; Swiss mice.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500005

Assessment of ventilatory neuromuscular drive in patients with obstructive sleep apnea
Provedor de dados: 56
Autores: Bittencourt,L.R.A.; Moura,S.M.T.; Bagnato,M.C.; Gregório,L.C.; Tufik,S.; Nery,L.E.
The presence of abnormalities of the respiratory center in obstructive sleep apnea (OSA) patients and their correlation with polysomnographic data are still a matter of controversy. Moderately obese, sleep-deprived OSA patients presenting daytime hypersomnolence, with normocapnia and no clinical or spirometric evidence of pulmonary disease, were selected. We assessed the ventilatory control and correlated it with polysomnographic data. Ventilatory neuromuscular drive was evaluated in these patients by measuring the ventilatory response (VE), the inspiratory occlusion pressure (P.1) and the ventilatory pattern (VT/TI, TI/TTOT) at rest and during submaximal exercise, breathing room air. These analyses were also performed after inhalation of a hypercapnic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ventilatory neuromuscular drive; Sleep apnea; Polysomnography; Ventilatory control.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400005

Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
Provedor de dados: 56
Autores: Santos-Galduróz,R.F.; Galduróz,J.C.F.; Facco,R.L.; Hachul,H.; Tufik,S.
Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Isoflavone; Cognitive disorders; Aging; Information integration; Memory; Menopause.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100016

Do Caucasian and Asian clocks tick differently?
Provedor de dados: 56
Autores: Barbosa,A.A.; Pedrazzoli,M.; Koike,B.D.V.; Tufik,S.
The Period 3 and Clock genes are important components of the mammalian molecular circadian system. Studies have shown association between polymorphisms in these clock genes and circadian phenotypes in different populations. Nevertheless, differences in the pattern of allele frequency and genotyping distribution are systematically observed in studies with different ethnic groups. To investigate and compare the pattern of distribution in a sample of Asian and Caucasian populations living in Brazil, we evaluated two well-studied polymorphisms in the clock genes: a variable number of tandem repeats (VNTR) in PER3 and a single nucleotide polymorphism (SNP) in CLOCK. The aim of this investigation was to search for clues about human evolutionary processes related...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: PER3 gene; CLOCK gene; Circadian rhythms; Asian; Caucasian; Ethnic.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000100013

A comparison of public and private obstructive sleep apnea clinics
Provedor de dados: 56
Autores: Zonato,A.I.; Bittencourt,L.R.; Martinho,F.L.; Baiard,P.; Togeiro,S.M.; Benedito-Silva,A.A.; Tufik,S.
The aim of the present study was to compare the clinical findings and polysomnography results obtained at public and private clinics in Brazil, the follow-up after diagnosis, and the therapeutic aspects related to continuous positive airway pressure. Patients who snore and who have obstructive sleep apnea were retrospectively divided into two groups, i.e., public clinic (N = 307) and private clinic (N = 317). Data concerning age, sex, body mass index (BMI), neck circumference, medical history, sleepiness scale, follow-up after diagnosis, and acceptance of continuous positive airway pressure therapy were collected. Mean age was 50 ± 12 (range: 15-80) for public patients and 48 ± 12 years (range: 19-91) for private patients. Mean BMI was 30 ± 6 (range:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Obstructive sleep apnea; Social class aspects; Anthropometric aspects; Continuous positive airway pressure.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100010

Repercussions of a sleep medicine outreach program
Provedor de dados: 56
Autores: Conway,S.G.; Tufik,S.; Frussa Filho,R.; Bittencourt,L.R.A.
Despite the high prevalence of sleep disorders, many healthcare professionals and lay people have little knowledge of Sleep Medicine. Mindful of such a reality, in 2001 the Sleep Institute of the Associação Fundo de Incentivo à Psicofarmacologia launched a campaign to increase Sleep Medicine awareness. Media features, exhibitions, inserts, and classes were used to reach 2,000,000 people and 55,000 healthcare professionals during the period from 2001 to 2004. To evaluate this program, we compared data for polysomnography referrals to the Institute in 2000 and in 2004. A total of 8805 referrals were evaluated (2000: 2164; 2004: 6641). Over the 4 years of the program, the number of beds increased by 43%; more women were referred (31 vs 37%; P &lt; 0.001),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep; Medical education; Clinical diagnosis; Diagnosis-related groups; Sleep-disorder breathing; Insomnia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000800008

Effects on prolactin secretion and binding to dopaminergic receptors in sleep-deprived lupus-prone mice
Provedor de dados: 56
Autores: Palma,B.D.; Hipolide,D.C.; Tufik,S.
Sleep disturbances have far-reaching effects on the neuroendocrine and immune systems and may be linked to disease manifestation. Sleep deprivation can accelerate the onset of lupus in NZB/NZWF1 mice, an animal model of severe systemic lupus erythematosus. High prolactin (PRL) concentrations are involved in the pathogenesis of systemic lupus erythematosus in human beings, as well as in NZB/NZWF1 mice. We hypothesized that PRL could be involved in the earlier onset of the disease in sleep-deprived NZB/NZWF1 mice. We also investigated its binding to dopaminergic receptors, since PRL secretion is mainly controlled by dopamine. Female NZB/NZWF1 mice aged 9 weeks were deprived of sleep using the multiple platform method. Blood samples were taken for the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Systemic lupus erythematosus; NZB/NZWF1 mice; Prolactin; Stress; Autoradiography; Dopamine transporter.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300012

Systematic head and neck physical examination as a predictor of obstructive sleep apnea in class III obese patients
Provedor de dados: 56
Autores: Martinho,F.L.; Tangerina,R.P.; Moura,S.M.G.T.; Gregório,L.C.; Tufik,S.; Bittencourt,L.R.A.
Our aim was to determine if anatomical abnormalities of the upper airway (UA) and facial skeleton of class III severely obese patients are related to the presence and severity of obstructive sleep apnea syndrome (OSAS). Forty-five patients (69% females, mean age 46.5 ± 10.8 years) with a body mass index (BMI) over 40 kg/m² underwent UA and facial skeletal examinations as well as polysomnography. Mean BMI was 49 ± 7 kg/m² and mean neck circumference was 43.4 ± 5.1 cm. Polysomnographic findings showed that 22% had a normal apnea-hypopnea index (AHI) and 78% had an AHI over 5. The presence of OSAS was associated with younger age (P = 0.02), larger neck circumference (P = 0.004), presence of a voluminous lateral wall (P = 0.0002), posteriorized soft palate (P...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Obesity; Obstructive sleep apnea syndrome; Snore; Physical examination; Predictors.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200008

Obese obstructive sleep apnea patients with tonsil hypertrophy submitted to tonsillectomy
Provedor de dados: 56
Autores: Martinho,F.L.; Zonato,A.I.; Bittencourt,L.R.A.; Soares,M.C.M.; Silva,R.F.N.; Gregório,L.C.; Tufik,S.
The physiopathology of obstructive sleep apnea-hypopnea syndrome (OSAHS) is multifactorial and obesity has been shown to be one of the main factors correlated with its occurrence. In obese patients with anatomical alterations of the upper airways it is often difficult to predict success for surgical correction since obesity is a limiting factor. Therefore, the aim of the present study was to evaluate the results of tonsillectomy in a specific group of patients, i.e., obese OSAHS patients with tonsil hypertrophy. Seven OSAHS patients with moderate obesity with obstructive palatine tonsil hypertrophy were submitted to tonsillectomy. All patients were submitted to pre- and postoperative appraisal of body mass index, otorhinolaryngology examination and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep apnea syndrome; Obesity; Surgery; Tonsillectomy; Apnea and hypopnea index.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000800017

Catecholamine response to exercise in individuals with different levels of paraplegia
Provedor de dados: 56
Autores: Steinberg,L.L.; Lauro,F.A.A.; Sposito,M.M.M.; Tufik,S.; Mello,M.T.; Naffah-Mazzacoratti,M.G.; Cavalheiro,E.A.; Silva,A.C.
The purpose of this study was to investigate the effect of the level of injury on the serum level of norepinephrine (Nor) and epinephrine (Epi) at rest and after maximal exercise in individuals with paraplegia. Twenty-six male spinal cord-injured subjects with complete paraplegia for at least 9 months were divided into two groups of 13 subjects each according to the level of injury, i.e., T1-T6 and T7-T12. Serum Nor and Epi concentrations were measured by HPLC-ECD, at rest (PRE) and immediately after a maximal ergospirometric test (POST). Statistical analysis was performed using parametric and non-parametric tests. Maximal heart rate, peak oxygen uptake, and PRE and POST Nor were lower in the T1-T6 than in the T7-T12 group (166 ± 28 vs 188 ± 10 bpm; 18.0 ±...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Catecholamines; Paraplegia; Exercise; Norepinephrine; Epinephrine; Spinal cord injury.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000800007

Effects of a physical fitness program on memory and blood viscosity in sedentary elderly men
Provedor de dados: 56
Autores: Antunes,H.K.; De Mello,M.T.; Santos-Galduróz,R.F.; Galduróz,J.C.F.; Lemos,V.Aquino; Tufik,S.; Bueno,O.F.A.
The aim of this study was to investigate the effects of a 6-month exercise program on cognitive function and blood viscosity in sedentary elderly men. Forty-six healthy inactive men, aged 60–75 years were randomly distributed into a control group (n=23) and an experimental group (n=23). Participants underwent blood analysis and physical and memory evaluation, before and after the 6-month program of physical exercise. The control group was instructed not to alter its everyday activities; the experimental group took part in the fitness program. The program was conducted using a cycle ergometer, 3 times per week on alternate days, with intensity and volume individualized at ventilatory threshold 1. Sessions were continuous and maximum duration was 60 min...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cognition; Elderly adults; Physical exercise.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900805

Pain-related diseases and sleep disorders
Provedor de dados: 56
Autores: Roizenblatt,M.; Rosa Neto,N.S.; Tufik,S.; Roizenblatt,S.
Pain and sleep share mutual relations under the influence of cognitive and neuroendocrine changes. Sleep is an important homeostatic feature and, when impaired, contributes to the development or worsening of pain-related diseases. The aim of the present review is to provide a panoramic view for the generalist physician on sleep disorders that occur in pain-related diseases within the field of Internal Medicine, such as rheumatic diseases, acute coronary syndrome, digestive diseases, cancer, and headache.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep disorders; Rheumatic diseases; Acute coronary syndrome; Irritable bowel syndrome; Cancer; Headache.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900001

Two pedigrees with restless legs syndrome in Brazil
Provedor de dados: 56
Autores: Esteves,A.M.; Pedrazzoli,M.; Bagnato,M.; Moreira,F.; Mello,M.T. de; Tufik,S.
Numerous studies have suggested a substantial genetic contribution in the etiology of the primary form of restless legs syndrome (RLS) and periodic leg movements (PLM). We describe the symptoms, the sleep profiles and physiological parameters of two families in which several members present RLS/PLM. The proband of family 1 is a 70-year-old woman and the proband of family 2 is a 57-year-old woman; both have exhibited the symptoms since the age of 20 years. All patients in both families were diagnosed with RLS according to the criteria of the International RLS Study Group. Polysomnographic recordings were performed to quantify and to describe PLM during sleep. Sleep parameters showed decreased sleep efficiency, increased sleep latency in the arousal index...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Restless legs syndrome; Periodic leg movements; Genetics; Sleep.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200005

Gentle handling temporarily increases c-Fos in the substantia nigra pars compacta
Provedor de dados: 56
Autores: Santos,C.A.; Andersen,M.L.; Lima,M.M.S.; Tufik,S.
Dopaminergic neurotransmission is involved in the regulation of sleep. In particular, the nigrostriatal pathway is an important center of sleep regulation. We hypothesized that dopaminergic neurons located in substantia nigra pars compacta (SNpc) could be activated by gentle handling, a method to obtain sleep deprivation (SD). Adult male C57/BL6J mice (N = 5/group) were distributed into non-SD (NSD) or SD groups. SD animals were subjected to SD once for 1 or 3 h by gentle handling. Two experiments were performed. The first determined the activation of SNpc neurons after SD, and the second examined the same parameters after pharmacologically induced dopaminergic depletion using intraperitoneal reserpine (2 mg/kg). After 1 or 3 h, SD and NSD mice were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep deprivation; Dopamine; C-Fos; Substantia nigra pars compacta; Gentle handling of mice.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001000015

Effect of smoking habits on sleep
Provedor de dados: 56
Autores: Conway,S.G.; Roizenblatt,S.S.; Palombini,L.; Castro,L.S.; Bittencourt,L.R.A.; Silva,R.S.; Tufik,S.
To evaluate the effect of smoking habits on sleep, data from 1492 adults referred to the Sleep Institute were accessed and divided into 3 categories of smoking status: current, former and non-smokers. Categories of pack-years (&lt;15 and ≥15) defined smoking severity. The association of smoking status and smoking severity with sleep was analyzed for sleep parameters, especially apnea and hypopnea index (AHI) ≥5, more than 5% of total sleep time (TST) spent with oxyhemoglobin saturation (SaO2) &lt;90%, and arousal index. The arousal index was higher among current (21 ± 17) and former smokers (20 ± 17) than non-smokers (17 ± 15; P &lt; 0.04). Former smokers had a higher percent of TST at SaO2 &lt;90% than non-smokers (9 ± 18 vs 6 ± 13; P &lt; 0.04). Former...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Smoking; Tobacco; Smoking cessation; Sleep; Sleep-disordered breathing.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800014

Gender and age differences in polysomnography findings and sleep complaints of patients referred to a sleep laboratory
Provedor de dados: 56
Autores: Silva,A.; Andersen,M.L.; De Mello,M.T.; Bittencourt,L.R.A.; Peruzzo,D.; Tufik,S.
Our objective was to examine the effet of gender on the sleep pattern of patients referred to a sleep laboratory. The data (questionnaires and polysomnographic recordings) were collected from a total of 2365 patients (1550 men and 815 women). The polysomnography permits an objective assessment of the sleep pattern. We included only polysomnography exams obtained with no more than one recording system in order to permit normalization of the data. Men had a significantly higher body mass index than women (28.5 ± 4.8 vs 27.7 ± 6.35 kg/m²) and had a significantly higher score on the Epworth Sleepiness Scale (10.8 ± 5.3 vs 9.5 ± 6.0), suggesting daytime sleepiness. Women had a significantly higher sleep latency than men, as well as a higher rapid eye movement...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep; Gender; Polysomnography; Apnea; Insomnia; Database.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200005

Sleep disorders, sleepiness and traffic safety: a public health menace
Provedor de dados: 56
Autores: Pandi-Perumal,S.R.; Verster,J.C.; Kayumov,L.; Lowe,A.D.; Santana,M.G.; Pires,M.L.N.; Tufik,S.; Mello,M.T.
Sleep disorders are not uncommon and have been widely reported throughout the world. They have a profound impact on industrialized 24-h societies. Consequences of these problems include impaired social and recreational activities, increased human errors, loss of productivity, and elevated risk of accidents. Conditions such as acute and chronic insomnia, sleep loss, excessive sleepiness, shift-work, jet lag, narcolepsy, and sleep apnea warrant public health attention, since residual sleepiness during the day may affect performance of daily activities such as driving a car. Benzodiazepine hypnotics and zopiclone promote sleep, both having residual effects the following day including sleepiness and reduced alertness. In contrast, the non-benzodiazepine...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep disorders; Sleepiness; Automobile and truck drivers; Automobile traffic; Public health.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000700003

Sawtooth waves during REM sleep after administration of haloperidol combined with total sleep deprivation in healthy young subjects
Provedor de dados: 56
Autores: Pinto Jr.,L.R.; Peres,C.A.; Russo,R.H.; Remesar-Lopez,A.J.; Tufik,S.
We sought to examine the possible participation of dopaminergic receptors in the phasic events that occur during rapid eye movement (REM) sleep, known as sawtooth waves (STW). These phasic phenomena of REM sleep exhibit a unique morphology and, although they represent a characteristic feature of REM sleep, little is known about the mechanisms which generate them and which are apparently different from rapid eye movements. STW behavior was studied in 10 male volunteers aged 20 to 35 years, who were submitted to polysomnographic monitoring (PSG). On the adaptation night they were submitted to the first PSG and on the second night, to the basal PSG. On the third night the volunteers received placebo or haloperidol and spent the whole night awake. On the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sawtooth waves; REM sleep; Sleep deprivation; Dopaminergic receptors; Rapid eye movements; Haloperidol.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500013

The reciprocal interaction between sleep and type 2 diabetes mellitus: facts and perspectives
Provedor de dados: 56
Autores: Martins,R.C.; Andersen,M.L.; Tufik,S.
Type 2 diabetes mellitus is a systemic disease characterized by intolerance to glucose and peripheral resistance to insulin. This endocrine disease affects fundamental mechanisms of the central nervous system and jeopardizes the balance of vital functions such as the cardiovascular and circadian rhythm. The increased prevalence of metabolic disorders in our society is aggravated by endemic voluntary postponement of bedtime and by the current sedentary lifestyle, leading to epidemic proportions of obese people. Diabetes and chronic loss of sleep share the fact that both affect millions and one is detrimental to the other. Indeed, sleep deficits have marked modulatory effects on glucose metabolism and insulin sensitivity and foster metabolic syndrome that...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diabetes; Metabolic syndrome; Obesity; Apnea; Sleep.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300001

Sleep patterns and sleep-related complaints of Brazilian interstate bus drivers
Provedor de dados: 56
Autores: Mello,M.T.; Santana,M.G.; Souza,L.M.; Oliveira,P.C.S.; Ventura,M.L.; Stampi,C.; Tufik,S.
Sleep-related complaints have become a highlight for physicians as well as public health administrators. Studies of sleep patterns and sleep-related complaints of shift workers have been useful in minimizing reduction in the quality of life due to the warping of the sleep-wake cycle. The objective of the present study was to assess patterns of sleep, sleep-related complaints as well as physical activity and scoring rates for depression and anxiety in interstate bus drivers. Data were obtained with a sleep questionnaire, with the Beck inventory for depression, and the State-Trait Anxiety Inventory (STAI). A total of 400 interstate bus drivers from the northern, southern, central-western and south-eastern regions of Brazil were interviewed. Sixty percent of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep; Sleep-related disorders; Shift workers; Depression; Anxiety; Physical activity.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100010

Relationship between the quality of life and the severity of obstructive sleep apnea syndrome
Provedor de dados: 56
Autores: Lopes,C.; Esteves,A.M.; Bittencourt,L.R.A.; Tufik,S.; Mello,M.T.
The effects of sleep disorders on the quality of life (QOL) have been documented in the literature. Excessive sleepiness and altered circadian rhythms may negatively affect ability to learn, employment, and interpersonal relations, and directly degrade QOL. The objective of the present study was to evaluate the impact of obstructive sleep apnea syndrome of varying severity on QOL. The study was conducted on 1892 patients aged 18 years or older referred by a physician to the Sleep Institute, São Paulo, with complaints related to apnea (snoring, excessive daytime sleepiness, hyperarousal, and fatigue). They were submitted to overnight polysomnography for the diagnosis of sleep disorders from August 2005 through April 2006. The patients completed the Epworth...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Physical activity; Obstructive sleep apnea syndrome; Quality of life; Sleepiness.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001000013